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Table 1 Characteristics of patients with intracranial meningioma who underwent LINAC-based radiation treatment

From: Effect of osteoporotic conditions on the development of peritumoral brain edema after LINAC-based radiation treatment in patients with intracranial meningioma

Characteristics PTBE (−) PTBE (+) Total p
Number (%) 91 (85.8) 15 (14.2) 106  
Sex, female, n (%) 70 (76.9) 12 (80.0) 82 (77.4) 0.792
Age, mean ± SD, y 62.4 ± 12.2 69.3 ± 9.3 63.3 ± 12.0 0.039
Imaging follow-up period, median (IQR), days 300.0 (173.0–622.0) 389.0 (243.0–892.0) 319.5 (176.8–635.0) 0.122
BMI, mean ± SD, kg/m2 24.5 ± 3.7 24.3 ± 2.9 24.5 ± 3.6 0.861
Classification of mean skull HU, n (%)     0.069
 Hypothetical normal (> 712.4) 49 (53.8) 4 (26.7) 53 (50.0)  
 Hypothetical osteopenia (> 611.7 and ≤ 712.4) 10 (11.0) 1 (6.7) 11 (10.4)  
 Hypothetical osteoporosis (≤ 611.7) 32 (35.2) 10 (66.7) 42 (39.6)  
Prior surgical resection, n (%) 38 (41.8) 4 (26.7) 42 (39.6) 0.268
Pathology, n (%)     0.472
 WHO grade I 26 (28.6) 3 (20.0) 29 (27.4)  
 WHO grade II 8 (8.8) 0 8 (7.5)  
 WHO grade III 4 (4.4) 1 (6.7) 5 (4.7)  
Location, n (%)     0.730
 Convexity 30 (33.0) 6 (40.0) 36 (34.0)  
 Parasagittal or parafalcine 19 (20.9) 5 (33.3) 24 (22.6)  
 Sphenoid ridge 9 (9.9) 1 (6.7) 10 (9.4)  
 Cerebellopontine angle 11 (12.1) 2 (13.3) 13 (12.3)  
 Posterior fossa 8 (8.8) 1 (6.7) 9 (8.5)  
 Parasellar or petroclival 11 (12.1) 0 11 (10.4)  
 Other 3 (3.3) 0 3 (2.8)  
GTV, mean ± SD, cc 7.6 ± 9.5 11.8 ± 9.4 8.2 ± 9.6 0.118
PTV, mean ± SD, cc 10.8 ± 12.7 16.4 ± 10.8 11.6 ± 12.6 0.110
Marginal radiation dose, mean ± SD, Gy 30.9 ± 11.4 27.5 ± 5.6 30.4 ± 10.8 0.262
Fractionation, n (%)     0.360
 SRS 16 (17.6) 3 (20.0) 19 (17.9)  
 hf-SRS (2–5 fractions) 51 (56.0) 10 (66.7) 61 (57.5)  
 hFSRT (6–10 fractions) 8 (8.8) 2 (13.3) 10 (9.4)  
 FSRT 16 (17.6) 0 16 (15.1)  
Dose per fraction, mean ± SD, Gy 7.0 ± 5.1 8.0 ± 5.2 7.1 ± 5.1 0.492
BED (α/β = 3), mean ± SD, Gy 89.0 ± 18.4 92.6 ± 21.0 89.5 ± 18.7 0.497
Past medical history, n (%)     
 Hypertension 38 (41.8) 7 (46.7) 45 (42.5) 0.722
 Diabetes 14 (15.4) 3 (20.0) 17 (16.0) 0.652
  1. LINAC, linear accelerator; PTBE, peritumoral brain edema; SD, standard deviation; IQR, interquartile range; BMI, body mass index; HU, Hounsfield unit; WHO, world health organization; GTV, gross tumor volume; PTV, planning target volume; Gy, gray; SRS, stereotactic radiosurgery; hf-SRS, hypofractionated stereotactic radiosurgery; hFSRT, hypofractionated stereotactic radiotherapy; FSRT, fractionated stereotactic radiotherapy; BED, biologically equivalent dose
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Radiation Oncology

ISSN: 1748-717X

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