Table 1 Characteristics of patients with intracranial meningioma who underwent LINAC-based radiation treatment
Characteristics | PTBE (−) | PTBE (+) | Total | p |
|---|---|---|---|---|
Number (%) | 91 (85.8) | 15 (14.2) | 106 | |
Sex, female, n (%) | 70 (76.9) | 12 (80.0) | 82 (77.4) | 0.792 |
Age, mean ± SD, y | 62.4 ± 12.2 | 69.3 ± 9.3 | 63.3 ± 12.0 | 0.039 |
Imaging follow-up period, median (IQR), days | 300.0 (173.0–622.0) | 389.0 (243.0–892.0) | 319.5 (176.8–635.0) | 0.122 |
BMI, mean ± SD, kg/m2 | 24.5 ± 3.7 | 24.3 ± 2.9 | 24.5 ± 3.6 | 0.861 |
Classification of mean skull HU, n (%) | 0.069 | |||
Hypothetical normal (> 712.4) | 49 (53.8) | 4 (26.7) | 53 (50.0) | |
Hypothetical osteopenia (> 611.7 and ≤ 712.4) | 10 (11.0) | 1 (6.7) | 11 (10.4) | |
Hypothetical osteoporosis (≤ 611.7) | 32 (35.2) | 10 (66.7) | 42 (39.6) | |
Prior surgical resection, n (%) | 38 (41.8) | 4 (26.7) | 42 (39.6) | 0.268 |
Pathology, n (%) | 0.472 | |||
WHO grade I | 26 (28.6) | 3 (20.0) | 29 (27.4) | |
WHO grade II | 8 (8.8) | 0 | 8 (7.5) | |
WHO grade III | 4 (4.4) | 1 (6.7) | 5 (4.7) | |
Location, n (%) | 0.730 | |||
Convexity | 30 (33.0) | 6 (40.0) | 36 (34.0) | |
Parasagittal or parafalcine | 19 (20.9) | 5 (33.3) | 24 (22.6) | |
Sphenoid ridge | 9 (9.9) | 1 (6.7) | 10 (9.4) | |
Cerebellopontine angle | 11 (12.1) | 2 (13.3) | 13 (12.3) | |
Posterior fossa | 8 (8.8) | 1 (6.7) | 9 (8.5) | |
Parasellar or petroclival | 11 (12.1) | 0 | 11 (10.4) | |
Other | 3 (3.3) | 0 | 3 (2.8) | |
GTV, mean ± SD, cc | 7.6 ± 9.5 | 11.8 ± 9.4 | 8.2 ± 9.6 | 0.118 |
PTV, mean ± SD, cc | 10.8 ± 12.7 | 16.4 ± 10.8 | 11.6 ± 12.6 | 0.110 |
Marginal radiation dose, mean ± SD, Gy | 30.9 ± 11.4 | 27.5 ± 5.6 | 30.4 ± 10.8 | 0.262 |
Fractionation, n (%) | 0.360 | |||
SRS | 16 (17.6) | 3 (20.0) | 19 (17.9) | |
hf-SRS (2–5 fractions) | 51 (56.0) | 10 (66.7) | 61 (57.5) | |
hFSRT (6–10 fractions) | 8 (8.8) | 2 (13.3) | 10 (9.4) | |
FSRT | 16 (17.6) | 0 | 16 (15.1) | |
Dose per fraction, mean ± SD, Gy | 7.0 ± 5.1 | 8.0 ± 5.2 | 7.1 ± 5.1 | 0.492 |
BED (α/β = 3), mean ± SD, Gy | 89.0 ± 18.4 | 92.6 ± 21.0 | 89.5 ± 18.7 | 0.497 |
Past medical history, n (%) | ||||
Hypertension | 38 (41.8) | 7 (46.7) | 45 (42.5) | 0.722 |
Diabetes | 14 (15.4) | 3 (20.0) | 17 (16.0) | 0.652 |