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Table 2 Associations between dosimetric/anthropometric variables and white blood cell grade ≥ 3 toxicity (median values reported)

From: Sarcopenia and dosimetric parameters in relation to treatment-related leukopenia and survival in anal cancer

 

All patients (n = 106)

WBC G3+ toxicity

No (n = 52)

Yes (n = 54)

P

Dosimetric variables

PBM

 Dmean (Gy)

32.0

32.1

31.9

0.390

 V10Gy (%)

87.3

86.1

88.1

0.574

 V20Gy (%)

79.5

78.7

80.0

0.733

 V30Gy (%)

61.0

62.1

60.4

0.742

 V40Gy (%)

35.5

36.6

34.9

0.242

 V50Gy (%)

7.8

8.4

6.2

0.054

 V < 10 Gy (cc)

174

185

149

0.373

 V < 20 Gy (cc)

294

306

277

0.397

 V < 30 Gy (cc)

547

557

536

0.552

 V < 40 Gy (cc)

879

912

843

0.356

 V < 50 Gy (cc)

1263

1291

1220

0.255

PTV (cc)

2614

2609

2624

0.604

PTV outside PBM (cc)

2435

2423

2446

0.570

Anthropometric variables

PBM volume (cc)

1363

1406

1330

0.041

Height (cm)

167

167

166

0.069

Weight (kg)

69.1

72.5

68.0

0.229

BMI (kg/m2)

25.2

24.9

25.7

0.845

BSA (m2)

1.78

1.81

1.77

0.133

  1. Bold indicates P-value < 0.05
  2. BMI body mass index, BSA body surface area, WBC white blood cell, PBM pelvic zone marrow, PTV planning target volume
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Radiation Oncology

ISSN: 1748-717X

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