Table 1 TrueSight Tumor 15 panel—Target genes NGS investigated for secondary resistance alterations after long-term treatment with cetuximab in DU145 and A431 cells
TruSight® Tumor 15 Gene | Target of Region |
|---|---|
AKT1 | E17K |
BRAF | V600E/K/R/M |
EGFR | Focal Amplification, Exon 19, Exon 20, G719A, Exon 21 (L858R), L861Q, S7681, T790M |
ERBB2 | Focal Amplification, p.E770_A771insAYVM (equivalent to p.A775_G776insYVMA) |
FOXL2 | C134W |
GNA11 | Q209L |
GNAQ | Q209L |
KIT | Exons 8,9,10,11,13,14,17,18 |
KRAS | Codons 12,13,59,61,117,146 |
MET | Focal Amplification |
NRAS | Codons 12,13,59,61,117,146 |
PDGFRA | Exons 12,14,18 |
PIK3CA | Exons 9,20 |
RET | M918T |
TP53 | Full CDS |