Diffusion-weighted MRI and 18F-FDG PET/CT in assessing the response to neoadjuvant chemoradiotherapy in locally advanced esophageal squamous cell carcinoma

Table 4 ROC analyses of ¹⁸F-FDG PET/CT and DW-MRI parameters to predict pCR-T

Parameters	AUC	SE	95% CI	Z statistic	P value	Youden index	Associated criterion	Sensitivity (%)	Specificity (%)
SUVmax-T_post	0.720	0.0804	0.563–0.846	2.743	*0.0061*	0.4409	≤ 4.42	78.57	65.52
MTV-T_post	0.819	0.0647	0.672–0.920	4.927	< *0.0001*	0.5172	≤ 5.076	100.00	51.72
TLG-T_post	0.828	0.0630	0.682–0.925	5.204	< *0.0001*	0.5517	≤ 14.65	100.00	55.17
ΔSUVmax-T	0.752	0.0752	0.598–0.869	3.346	*0.0008*	0.4874	≥ 0.7229	86.67	62.07
ΔMTV-T	0.685	0.101	0.528–0.817	1.836	0.0663	0.4299	≥ 0.8937	53.33	89.66
ADC_during	0.880	0.0602	0.704–0.962	6.325	< *0.0001*	0.7029	> 2.52	83.33	86.96
ADC_post	0.771	0.0842	0.588–0.900	3.114	*0.0018*	0.6234	> 2.68	90.91	71.43
ΔADC_during	0.851	0.0639	0.691–0.949	5.504	< *0.0001*	0.6522	> 0.53	100.0	65.22
Combined model*	0.914	0.0518	0.759–0.983	7.987	< *0.0001*	0.7636	≤ 0.475	90.00	86.36

P values less than 0.05 are indicated in bold italics
*Predicted probability of the combined model: P = e^(7.325 + 0.244*TLG-T_post-3.774*ADC_during)/(1 + e^(7.325 + 0.244*TLG-T_post-3.774*ADC_{dur ing}))
DW-MRI diffusion-weighted magnetic resonance imaging; ¹⁸F-FDG-PET/CT ¹⁸F-Fluorodeoxyglucose-positron emission tomography/computed tomography; pCR-T complete response of primary tumor; SUVmax maximum standard uptake value; MTV metabolic tumor volume; TLG total lesion glycolysis; ADC apparent diffusion coefficient; ROC receiver operating characteristic; AUC areas under the curve; SE standard error; CI confidence interval

ISSN: 1748-717X