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Table 4 ROC analyses of 18F-FDG PET/CT and DW-MRI parameters to predict pCR-T

From: Diffusion-weighted MRI and 18F-FDG PET/CT in assessing the response to neoadjuvant chemoradiotherapy in locally advanced esophageal squamous cell carcinoma

Parameters AUC SE 95% CI Z statistic P value Youden index Associated criterion Sensitivity (%) Specificity (%)
SUVmax-Tpost 0.720 0.0804 0.563–0.846 2.743 0.0061 0.4409  ≤ 4.42 78.57 65.52
MTV-Tpost 0.819 0.0647 0.672–0.920 4.927  < 0.0001 0.5172  ≤ 5.076 100.00 51.72
TLG-Tpost 0.828 0.0630 0.682–0.925 5.204  < 0.0001 0.5517  ≤ 14.65 100.00 55.17
ΔSUVmax-T 0.752 0.0752 0.598–0.869 3.346 0.0008 0.4874  ≥ 0.7229 86.67 62.07
ΔMTV-T 0.685 0.101 0.528–0.817 1.836 0.0663 0.4299  ≥ 0.8937 53.33 89.66
ADCduring 0.880 0.0602 0.704–0.962 6.325  < 0.0001 0.7029  > 2.52 83.33 86.96
ADCpost 0.771 0.0842 0.588–0.900 3.114 0.0018 0.6234  > 2.68 90.91 71.43
ΔADCduring 0.851 0.0639 0.691–0.949 5.504  < 0.0001 0.6522  > 0.53 100.0 65.22
Combined model* 0.914 0.0518 0.759–0.983 7.987  < 0.0001 0.7636  ≤ 0.475 90.00 86.36
  1. P values less than 0.05 are indicated in bold italics
  2. *Predicted probability of the combined model: P = e^(7.325 + 0.244*TLG-Tpost-3.774*ADCduring)/(1 + e^(7.325 + 0.244*TLG-Tpost-3.774*ADCdur ing))
  3. DW-MRI diffusion-weighted magnetic resonance imaging; 18F-FDG-PET/CT 18F-Fluorodeoxyglucose-positron emission tomography/computed tomography; pCR-T complete response of primary tumor; SUVmax maximum standard uptake value; MTV metabolic tumor volume; TLG total lesion glycolysis; ADC apparent diffusion coefficient; ROC receiver operating characteristic; AUC areas under the curve; SE standard error; CI confidence interval