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Table 3 The association between dental-related factors and ORN post dental extraction (N = 389)

From: Predictors of osteoradionecrosis following irradiated tooth extraction

Variable All extracted teeth No ORN, n (%) ORN, n (%) p value
Tooth type     
 Upper single-rooted 56 (14.4%) 56 (15.7%) 0 (0.0%)  
 Upper double-rooted 135 (34.7%) 122 (34.2%) 13 (40.6%) < 0.001a*
 Lower single-rooted 85 (21.9%) 84 (23.5%) 1 (3.1%)  
 Lower double-rooted 113 (29.0%) 95 (26.6%) 18 (56.2%)  
Tooth pathology     
 Periapical periodontitis related 145 (37.3%) 136 (39.0%) 9 (32.1%) 0.001a*
 Caries-related 178 (45.7%) 164 (47.0%) 14 (50.0%)  
 Perio-related 42 (10.8%) 42 (12.0%) 0 (0.0%)  
 Mixed caries-perio related 8 (2.1%) 5 (1.4%) 3 (10.7%)  
 Others 4 (1.1%) 2 (0.6%) 2 (7.1%)  
 No data 12 (3.1%)    
Procedure     
 Simple extraction 259 (66.6%) 249 (69.9%) 10 (35.7%) < 0.001b*
 Surgery 125 (32.1%) 107 (30.1%) 18 (64.3%)  
 No data 5 (1.3%)    
Operator     
 Dental officer/postgraduate 269 (69.2%) 252 (71.0%) 17 (63.0%) 0.379b
 Specialist 113 (29.0%) 103 (29.0%) 10 (37.0%)  
 No data 7 (1.8%)    
Primary closure     
 Yes 198 (50.9%) 178 (50.0%) 20 (71.4%) 0.029b*
 No 186 (47.8%) 178 (50.0%) 8 (28.6%)  
 No data 5 (1.3%)    
Antibiotic post-extraction     
 Antibiotics prescribed 339 (87.1%) 315 (88.7%) 24 (85.7%) 0.547a
 No antibiotic prescribed 44 (11.3%) 40 (11.3%) 4 (14.3%)  
 No data 6 (1.5%)    
Within target volume     
 Yes 107 (27.5%) 87 (45.3%) 20 (90.9%) < 0.001b*
 No 107 (27.5%) 105 (54.7%) 2 (9.1%)  
 No data 175 (45.0%)    
Total dose     
 Below 60 Gy 122 (31.4%) 122 (62.6%) 0 (0.0%) < 0.001b*
 60 Gy and above 95 (24.4%) 73 (37.4%) 22 (100.0%)  
 No data 172 (44.2%)    
Time of extraction post radiotherapy     
 3 months to 1 year 13 (3.3%) 13 (3.6%) 0 (0.0%) 0.001a*
 1–5 years 103 (26.5%) 85 (23.8%) 18 (56.2%)  
 > 5 years 273 (70.2%) 259 (72.5%) 14 (43.8%)  
  1. *p < 0.05
  2. aFisher’s exact test
  3. bPearson chi-square test