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Table 5 Gastrointestinal toxicity (CTCAE version 5.0)

From: Stereotactic body radiation therapy for the treatment of localized prostate cancer in men with underlying inflammatory bowel disease

Toxicity

Time to toxicity (months)

IBD subtype

Risk group

Total dose (cGy)

IDL (%)

Rectal Dmax (cGy)

Pre-SBRT IBD meds

Grade 3 proctitis

 < 1

UC

Int

3500

84

3656

Mesalamine

Grade 2 proctitis

29

UC

Low

3500

85

3852

Prednisone

Grade 2 proctitis

22

UC

Int

3500

83

3860

Mesalamine

Grade 2 hemorrhoids

10

CD

High

3500

86

3839

Methotrexate

Grade 1 rectal hemorrhage

 < 1

CD

High

3500

86

3839

Methotrexate

Grade 1 hemorrhoids

22

UC

Int

3500

83

3860

Mesalamine