Risk factors for venous thromboembolism induced by prolonged bed rest during interstitial brachytherapy for gynecological cancer: a retrospective study

Table 3 Univariate analysis for the incidence or worsening of venous thromboembolism

	Patients	Incidence or worsening of VTE	p-value
Age
< 61 years	23	2	0.23
≥ 61 years	24	5
Primary
Cervix	37	7	0.16
Others	10	0
Body mass index
> 22 kg/m²	29	3	0.27
≤ 22 kg/m²	18	4
Tumor size
< 61 mm	23	3	0.53
≥ 61 mm	24	4
PLN metastasis
Negative	17	3	0.50
Positive	30	4
PALA metastasis
Negative	35	6	0.42
Positive	12	1
Initial onset/recurrence
Initial onset	33	5	0.65
Recurrence	14	2
Duration of bed rest
≤ 2 days	34	3	0.08
≥ 3 days	13	4
Number of inserted needles
≤ 15	29	4	0.55
≥ 16	18	3
Volume of CTV
≤ 54.9 cc	24	3	0.48
> 54.9 cc	23	4
VTE before ISBT
Negative	33	0	< 0.01
Positive	14	7
Caprini score
≤ 6	33	1	< 0.01
≥ 7	14	6
Rogers score
≤ 4	31	6	0.40
≥ 5	16	1
Difference of D-dimer value between pre-ISBT and the day of needle removal
< + 1 µg/mL	41	2	< 0.01
≥ + 1	6	5
Difference of D-dimer value between pre-ISBT and the day following needle removal
< + 1 µg/mL	34	0	< 0.01
≥ + 1	13	7

VTE venous thromboembolism, SCC squamous cell carcinoma, PLN pelvic lymph node metastasis, PALA para-aortic lymph node, CCRT concurrent chemoradiotherapy, RT radiotherapy, EBRT external beam radiotherapy, ISBT interstitial brachytherapy, CTV clinical target volume, DVT deep vein thrombosis

ISSN: 1748-717X