Table 2 Biologically corrected EQD2 dose with the inclusion of uniform 45 Gy from external beam radiotherapy prior to the SFRT boost. Comparator data derives from brachytherapy treatments while the last column reports the data from the SBRT study of Albuquerque et al. [5]. The ranges are reported in square brackets
Structure | Param | Obj | SFRT_1 | SFRT_2 | SBRT | Comparator | Albuquerque |
|---|---|---|---|---|---|---|---|
CTV | D90% | 84.25 Gy | 84.25 | 84.25 | 84.25 | 88.2 ± 1.8 | – |
V45Gy (150%) | ≥ 50–55% | 43.1 ± 7.5 [33.0,55.9] | 56.6 ± 5.6 [45.4,64.8] | 2.3 ± 3.8 [0,10.6] | 61.0 ± 3.8 [56.0,66.4] | – | |
V60Gy (200%) | ≥ 30% | 15.4 ± 5.6 [6.9,23.9] | 26.8 ± 6.6 [17.3,34.2] | 0 [0,0] | 37.2 ± 3.6 [31.6,41.8] | – | |
PTV2mm | D90% | 84.25 GY | 72.6 ± 2.2 [69.2,74.7] | 72.9 ± 2.2 [72.1,75.3] | 72.4 ± 2.1 [69.9,74.4] | – | – |
PTV5mm | D90% | 84.25 Gy | 67.6 ± 2.1 [64.5,70.3] | 68.2 ± 2.5 [63.8,71.0] | 67.4 ± 2.1 [64.2,69.3] | – | – |
Bladder | D2cm3 | ≤ 80.0 Gy | 76.6 ± 4.9 [71.7,88.5] | 76.9 ± 5.2 [72.6,89.3] | 75.0 ± 5.5 [66.7,86.4] | 66.5 ± 5.9 [56.8,86.9] | 99.6 (*) |
Rectum | D2cm3 | ≤ 65.0 Gy | 59.5 ± 5.5 [53.5,72.6] | 58.0 ± 5.0 [53.7,68.4] | 57.8 ± 7.2 [50.6,74.9] | 53.1 ± 4.1 [48.0,58.9] | 90.6 (*) |
Sigmoid | D2cm3 | ≤ 70.0 Gy | 45.4 ± 3.2 [44.0,53.7] | 45.4 ± 3.1 [43.5,53.1] | 45.2 ± 2.5 [43.4,50.6] | 61.5 ± 2.7 [57.0,66.2] | 80.7 (*) |
Bowel | D2cm3 | ≤ 65.0 Gy | 52.8 ± 7.7 [43.9,66.1] | 52.9 ± 8.4 [45.0,67.8] | 54.1 ± 9.1 [45.1,67.0] | 54.3 ± 7.1 [46.3,67.3] | 67.9 (*) |