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Table 2 Hippocampi volume and change in volume between MRIs according to the D40% groups

From: Role of hippocampal location and radiation dose in glioblastoma patients with hippocampal atrophy

 

Hhomo-G1

Hcontra-G1

Hhomo-G2

Hcontra-G2

Hhomo-G3

Hcontra-G3

 

Median volume (min–max) (mm3)

MRIdosimetric

3700 (3070–4410)

3460 (2880–4010)

3540 (2330–4850)

3450 (2180–4680)

3250 (650–4320)

3640 (2000–4350)

MRIrelapse

3260 (3120–4390)

3340 (2760–4070)

3050 (1960–4630)

3380 (2340–4440)

3030 (610–3970)

3500 (2030–4120)

MRIlast

3200 (3020–3560)

3350 (3200–3620)

2670 (1970–4230)

3440 (1860–5780)

3080 (400–3620)

3310 (2000–4350)

 

Median reduction between MRIdosimetric and MRIrelapse

Volume (mm3)

− 200 (+ 180 to − 1140)

− 70 (+ 220 to − 590)

− 420 (+ 840 to − 950)

− 100 (+ 330 to − 690)

− 220 (+ 580 to − 2750)

− 220 (+ 500 to − 1160)

%

− 5.4 (+ 5.5 to − 26.4)

− 1.9 (+ 7.6 to − 17.6)

− 10.6 (+ 36 to − 25.9)

− 3.1 (+ 10.8 to − 17.8)

− 8.7 (+ 21.5 to − 80.9)

− 5.3 (+ 15.9 to − 32.0)

 

Median reduction between MRIrelapse and MRIlast

Volume (mm3)

− 60 (+ 250 to − 1370)

+ 10 (+ 100 to − 500)

− 150 (+ 960 to − 970)

− 20 (+ 1390 to − 1370)

− 270 (+ 500 to − 1470)

− 210 (+ 1170 to − 1300)

%

− 1.7 (+ 7.5 to − 31.2)

+ 0.3 (+ 3.2 to − 13.3)

− 4.8 (+ 35 to − 29.5)

− 0.6 (+ 31.7 to − 42.4)

− 12.4 (+ 16.0 to − 60.2)

− 6.9 (+ 47.6 to − 39.4)

 

Median reduction between MRIdosimetric and MRIlast

Volume (mm3)

− 130 (+ 130 to − 1390)

− 180 (+ 320 to − 600)

− 620 (+ 500 to − 1400)

− 190 (+ 1720 to − 1230)

− 500 (+ 150 to − 1570)

− 190 (+ 840 to − 2010)

%

− 3.5 (+ 4.2 to − 31.5)

− 5.1 (+ 11.1 to − 15.5)

− 20.9 (+ 14.7 to − 38.1)

− 5.6 (+ 42.4 to − 39.8)

− 17.6 (+ 5 to − 61.8)

− 5.4 (+ 23.9 to − 50.1)

  1. In group 1 (G1: n = 6), in both hippocampi, the D40% was < 7.4 Gy; in group 2 (G2: n = 13), the Hcontra D40% was < 7.4 Gy; and in group 3 (G3: n = 30), the D40% for both hippocampi was > 7.4 Gy