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Table 2 Dosimetric comparison of target and organs at risk before and after spacer insertion

From: Phase II study of stereotactic body radiotherapy with hydrogel spacer for prostate cancer: acute toxicity and propensity score-matched comparison

 

Before spacer (n = 40)

After spacer (n = 40)

P

Mean (± S.D.)

Mean (± S.D.)

Prostate, ml

42.2 (± 21.4)

39.6 (± 20.8)

 < 0.01

Seminal vesicles, ml

13.6 (± 5.3)

13.2 (± 5.3)

0.34

PTV, ml

100.1 (± 36.2)

99.1 (± 36.7)

0.43

Bladder, ml

202.1 (± 102.8)

274.7 (± 132.2)

 < 0.01

Rectum, ml

49.0 (± 13.0)

49.1 (± 22.2)

0.96

PTV mean, Gy

37.3 (± 0.3)

37.2 (± 0.3)

0.32

PTV max, Gy

39.1 (± 0.6)

39.0 (± 0.6)

0.20

Urethra max, Gy

38.3 (± 0.6)

38.3 (± 0.6)

0.96

Rectum mean, Gy

16.4 (± 1.2)

15.1 (± 1.4)

 < 0.01

Rectum max, Gy

38.3 (± 0.6)

36.9 (± 1.8)

 < 0.01

Rectum V100%, %

3.0 (± 1.2)

0.4 (± 0.6)

 < 0.01

Rectum V90%, %

9.6 (± 2.2)

2.2 (± 2.2)

 < 0.01

Rectum V80%, %

14.9 (± 2.7)

4.9 (± 3.5)

 < 0.01

Rectum V75%, %

17.5 (± 2.9)

6.8 (± 4.1)

 < 0.01

Rectum V50%, %

34.6 (± 3.1)

27.3 (± 5.9)

 < 0.01

Bladder mean, Gy

12.4 (± 3.4)

10.6 (± 3.8)

 < 0.01

Bladder max, Gy

38.7 (± 0.6)

38.5 (± 0.6)

0.30

Bladder V100%, %

4.8 (± 2.1)

3.8 (± 1.8)

 < 0.01

Bladder V50%, %

26.2 (± 9.0)

22.6 (± 9.9)

 < 0.01

Femoral head max, Gy

15.9 (± 1.9)

15.0 (± 1.4)

0.01

Penile bulb max, Gy

28.9 (± 8.1)

24.0 (± 10.6)

 < 0.01

  1. Rectal volume including the rectal contents
  2. PTV planning target volume