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Table 1 Median values (ranges) of CTV and PTV coverage measures at baseline and after re-optimization, and two-sided significances of changes in distributions of these measures following re-optimization

From: Cardiac-sparing radiotherapy for locally advanced non-small cell lung cancer

Coverage measure (IDEAL-CRT limit)

At baseline

After MDHeart reduction

After VHeart-50-Gy reduction

After VLAwall-63-Gy reduction

DPTV-90%* (≥ 95% prescribed dose)

98.6% (96.7, 99.0%)

97.9% (95.7, 98.9%)

p = 6 × 10–4

98.0% (96.3, 98.9%)

p = 2 × 10–4

98.4% (95.3, 99.0%)

p = 0.31

DPTV-98% (≥ 90% prescribed dose)

96.7% (92.4, 97.9%)

95.0% (90.7, 97.3%)

p = 4 × 10–4

95.1% (91.5, 97.5%)

p = 2 × 10–4

96.4% (90.4, 97.7%)

p = 0.09

DCTV-99% (≥ 95% prescribed dose)

98.0% (96.5, 98.6%)

97.6% (95.7, 98.4%)

p = 7 × 10–3

97.7% (96.1, 98.4%)

p = 8 × 10–3

97.9% (95.6, 98.6%)

p = 0.27

DPTV-99.5% (non-protocol measure)

95.2% (86.5, 96.9%)

91.9% (86.7, 96.4%)

p = 1 × 10–3

92.5% (86.0, 96.4%)

p = 3 × 10–4

94.6% (86.9, 96.6%)

p = 0.09

  1. *DStructure-X% denotes the minimum percentage of the prescribed dose covering the most highly irradiated X% of a structure