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Table 1 Median values (ranges) of CTV and PTV coverage measures at baseline and after re-optimization, and two-sided significances of changes in distributions of these measures following re-optimization

From: Cardiac-sparing radiotherapy for locally advanced non-small cell lung cancer

Coverage measure (IDEAL-CRT limit) At baseline After MDHeart reduction After VHeart-50-Gy reduction After VLAwall-63-Gy reduction
DPTV-90%* (≥ 95% prescribed dose) 98.6% (96.7, 99.0%) 97.9% (95.7, 98.9%)
p = 6 × 10–4
98.0% (96.3, 98.9%)
p = 2 × 10–4
98.4% (95.3, 99.0%)
p = 0.31
DPTV-98% (≥ 90% prescribed dose) 96.7% (92.4, 97.9%) 95.0% (90.7, 97.3%)
p = 4 × 10–4
95.1% (91.5, 97.5%)
p = 2 × 10–4
96.4% (90.4, 97.7%)
p = 0.09
DCTV-99% (≥ 95% prescribed dose) 98.0% (96.5, 98.6%) 97.6% (95.7, 98.4%)
p = 7 × 10–3
97.7% (96.1, 98.4%)
p = 8 × 10–3
97.9% (95.6, 98.6%)
p = 0.27
DPTV-99.5% (non-protocol measure) 95.2% (86.5, 96.9%) 91.9% (86.7, 96.4%)
p = 1 × 10–3
92.5% (86.0, 96.4%)
p = 3 × 10–4
94.6% (86.9, 96.6%)
p = 0.09
  1. *DStructure-X% denotes the minimum percentage of the prescribed dose covering the most highly irradiated X% of a structure