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Table 1 Endpoint definitions: brachial plexus toxicity grading scales

From: Estimating the tolerance of brachial plexus to hypofractionated stereotactic body radiotherapy: a modelling-based approach from clinical experience

 

CTCAE Version 3.0 [21]

CTCAE Version 4.0 [22]

Modified LENT-SOMA scale [23]

Grade 1

Asymptomatic brachial plexopathy

Asymptomatic effects

Mild sensory deficits, no pain, no treatment required

Grade 2

Symptomatic brachial plexopathy without interfering with activities of daily living (ADL)

Moderate symptoms limiting ADL

Moderate sensory deficits, tolerable pain, mild arm weakness

Grade 3

Symptomatic brachial plexopathy and interfering with ADL

Severe symptoms limiting self care ADL

Continuous paresthesia, with incomplete paresis, pain medication required

Grade 4

Disabling brachial plexopathy

N/A

Complete paresis, excruciating pain, muscle atrophy, regular pain medication required

  1. CTCAE common terminology criteria for adverse events, LENT late effects normal tissues, SOMA subjective, objective, management, analytic, ADL activities of daily living