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Table 2 Treatment-related toxicities during CCRT

From: Concurrent chemoradiotherapy with S-1 compared with concurrent chemoradiotherapy with docetaxel and cisplatin for locally advanced esophageal squamous cell carcinoma

Toxicities DP group
(n = 103)
S-1 group
(n = 72)
p value
Overall toxicity ≥ 3 47 (45.6%) 16 (22.2%) 0.002
Grade 3 31 (30.1%) 13 (18.1%) 0.079
Grade 4 16 (15.5%) 3 (4.1%) 0.024
Hematological toxicities ≥ 3    
Anemia 7 (6.8%) 4 (5.6%) 0.767
Leukopenia 35 (34.0%) 9 (12.5%) 0.001
Neutropenia 30 (29.1%) 7 (9.7%) 0.002
Thrombocytopenia 6 (5.8%) 2 (2.8%) 0.473
Non-hematological toxicities ≥ 3    
Esophagitis 24 (23.3%) 12 (16.7%) 0.344
Nausea/vomiting 10 (9.7%) 1 (1.4%) 0.028
Mucositis 4 (3.9%) 3 (4.1%) 1.000
Fatigue 9 (8.7%) 5 (6.9%) 0.781
Pneumonitis 5 (4.9%) 3 (4.1%) 1.000