Comparison of hypofractionation and standard fractionation for post-prostatectomy salvage radiotherapy in patients with persistent PSA: single institution experience

Table 2 Univariate analysis for PSA failure-free survival after salvage radiotherapy

Variable	Hazard ratio (HR)	95% CI	p-value
Age, yrs Cont	1.01	0.95–1.08	0.99
First post- prostatectomy PSA Cont	1.02	1.0–1.04	0.03
PreRT PSA Cont	1.05	0.997–1.09	0.06
Fractionation schedule
66 Gy/33x	1.0
52.5 Gy/20x	2.2	1.0–4.6	0.03
ADT during RT
No	1.0
Yes	3.3	1.2–8.6	0.02
Final pathology Grade Group Gleason score			Overall p = 0.02
1	1.0
2	0.28	0.05–1.45	0.13
3	1.11	0.25–4.92	0.89
4	0.38	0.05–2.69	0.33
5	1.33	0.27–6.65	0.73
pT stage			Overall p = 0.03
T1–T2a	1.0
T2b–T2c	2.21	0.267–18.42	0.46
T3–T4	5.23	0.71–38.83	0.11
SVI
No	1.0
Yes	1.88	0.91–3.86	0.09
Positive surgical margins
No	1.0
Yes	2.04	0.99–4.2	0.052
ECE
No	1.0
Yes	1.99	0.99–4.14	0.06

yrs years, cont continuous, PSA prostate-specific antigen, ADT androgen deprivation therapy, RT radiotherapy, SVI seminal vesicle invasion, ECE extracapsular extension

ISSN: 1748-717X