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Table 5 Correlation between risk factors and RP using binary logistic regression analysis

From: Risk factors for radiation pneumonitis in lung cancer patients with subclinical interstitial lung disease after thoracic radiation therapy

Factors

Grade ≥ 2 RP

Grade ≥ 3 RP

Odds ratio (OR)

95% CI

p value

OR

95% CI

p value

MLD (≥ 12.0 Gy vs. < 12.0 Gy)

2.480

1.006–6.113

0.049

Tumor located in lower lobe

2.311

0.898–5.943

0.082

Chemotherapy with gemcitabine in the past

3.209

1.018–10.113

0.046

V5 (≥ 50%vs. < 50%)

3.429

1.056–11.140

0.040

Percentage of lung volume affected in subclinical ILD ≥ 25%

4.861

1.237–19.104

0.024

  1. RP, radiation pneumonitis; MLD, mean lung dose; V5, percentage of lung volume receiving ≥ 5 Gy; ILD, interstitial lung disease; CI, confidence interval