|
Characteristic
|
No radiation pneumonitis (n = 85)
|
Symptomatic radiation pneumonitis (n = 8)
|
p value
|
|---|
|
Contralateral lung V5, %
| | |
0.05
|
|
Median
|
3.1%
|
7.4%
| |
|
Range
|
0.0–33.6%
|
4.2–53.4%
| |
|
Ipsilateral lung V30, %
| | |
0.001
|
|
Median
|
3.3%
|
9.6%
| |
|
Range
|
0.8–11.6%
|
6.5–12.8%
| |
|
Ipsilateral lung V40, %
| | |
0.003
|
|
Median
|
2.1%
|
5.8%
| |
|
Range
|
0.5–8.1%
|
3.6–8.8%
| |
|
Total lung V5, %
| | |
0.001
|
|
Median
|
14.7%
|
29.1%
| |
|
Range
|
4.2–46.9%
|
18.2–56.9%
| |
|
Total lung V10, %
| | |
0.001
|
|
Median
|
8.4%
|
21.7%
| |
|
Range
|
2.2–34.6%
|
10.8–38.4%
| |
|
MVLS from 12.4 Gy, cm3
| | |
0.31
|
|
Median
|
3172 cm3
|
2132 cm3
| |
|
Range
|
969–6807 cm3
|
1439–3592 cm3
| |
|
MVLS from 13.5 Gy, cm3
| | |
0.31
|
|
Median
|
3196 cm3
|
2157 cm3
| |
|
Range
|
980–6829 cm3
|
1452–3603 cm3
| |
|
Total lung V15, %
| | |
0.001
|
|
Median
|
5.4%
|
13.2%
| |
|
Range
|
1.2–25.8%
|
7.8–18.8%
| |
|
Total lung V20, %
| | |
0.001
|
|
Median
|
3.4%
|
9.1%
| |
|
Range
|
0.8–19.4%
|
5.3–12.8%
| |
|
Total lung V25, %
| | |
0.001
|
|
Median
|
2.4%
|
6.7%
| |
|
Range
|
0.6–15.2%
|
3.6–9.6%
| |
|
Total lung V30, %
| | |
0.002
|
|
Median
|
1.8%
|
5.1%
| |
|
Range
|
0.5–12.1%
|
2.4–7.4%
| |
|
Total lung V40, %
| | |
0.003
|
|
Median
|
1.1%
|
3.3%
| |
|
Range
|
0.3–8.6%
|
1.1–4.7%
| |
- Abbreviations: Vdose is the percent of lung receiving greater than the “dose” (in Gy). Symptomatic Radiation Pneumonitis = RTOG G3 + or CTCAE G2 + RP. MVLS = Minimum Volume of Lung Spared
- p values from Wilcoxon Rank Sum tests, with all values Bonferroni adjusted. Bolded p values indicate statistical significance
