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Fig. 2 | Radiation Oncology

Fig. 2

From: Longitudinal MRI study after carbon ion and photon irradiation: shorter latency time for myelopathy is not associated with differential morphological changes

Fig. 2

Latency times until occurrence of morphological alterations and neurological distortions after irradiation with photons (green) or carbon ions (red). For both irradiation modalities, the morphological alterations outside the spinal cord (BMC, CA v, CA d) occurred significantly earlier than morphological alterations inside the spinal cord (edema, CA, syrinx) and the start of neurological distortions (P I, P II). Box plots (25%/75%) show median (solid line) with 10%/90% percentiles (whiskers). BMC = bone marrow conversion, CA v/d = contrast agent accumulation in the ventral and dorsal musculature outside of the spinal cord, respectively, CA = contrast agent accumulation inside the spinal cord, P I (paresis I) = at least one forelimb showed signs of neurological dysfunction, P II (paresis II) = both forelimbs showed signs of paralysis. *p < 0.05, ***p < 0.001. Note: Statistical comparisons between MRI endpoints outside the spinal cord (BMC, CA v/d) or MRI endpoints inside the spinal (edema, CA, syrinx) cord plus neurological endpoints (P I, P II) were non-significant while any combination between these two groups of endpoints were significant

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