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Table 5 Overview of available literature

From: MR-guided stereotactic body radiation therapy for primary cardiac sarcomas

Primary sarcomas

Publication

Histology

Localization

Number of patients

Dose

Response rate

Survival

Toxicities

Aoka 2004 [1]

Primary cardiac angiosarcoma

Right atrium

1

64 Gy/4 Gy carbon-ion radiotherapy, followed by recombinant Interleukin-2

Locally SD, lung metastases after 4 months

Alive at 1.5 years after treatment

None

Bonomo 2015 [17]

Primary cardiac angiosarcoma and malignant melanoma metastasis

Cardiac lesions

3

3 × 8 Gy (80% ID)

5 × 6 Gy (80% ID)

PR – 2 (PCA)

SD – 1 (MM)

Alive at 6 months after treatment, after 8 months 1 patient died (lung metastasis)

None

Gabani 2019 [13]

Primary cardiac angiosarcoma

Right atrium (7.3 cm)

1

5 × 6 Gy daily, concurrent paclitaxel (80 mg/m2) weekly

After 6 weeks: ipilimumab/nivolumab → PR: 4.1 cm but progression of pulmonary metastasis

Alive at 6 months after treatment

Esophagitis

Isambert 2013 [3]

Primary cardiac sarcoma

Cardiac lesions

124 of which 24 were treated with radiotherapy: 18 adjuvant and 6 definitive

Median dose 50 Gy (range 10–64 Gy). 23 followed by chemotherapy

Benefit in PFS

mOS 17.2 months (all), better survival with radiotherapy (HR 0.54, inivariate; HR 0.62 multivariate analysis)

n.a.

Nakamura-Horigome 2008 [18]

Primary cardiac angiosarcoma

Right atrium, right ventricular wall

1

42 Gy/2 Gy Simultaneous radiochemotherapy with docetaxel & 12 months low dose docetaxel

SD

Alive at 12 months after treatment

Esophagitis

Pötter 1989 [19]

Primary cardiac angiosarcoma

Right atrium

1

40 Gy/1.8 Gy whole heart/mediastinum, boost with 60 Gy to the right atrium, simultaneous radiochemotherapy

Macroscopic no tumor at autopsy

OS 15 months, died of progressive brain metastases

None

Soltys 2008 [20]

Pulmonary artery intimal sarcoma

Left pulmonary artery

1

3 × 11 Gy (79% ID)

Improvement of dyspnea

Died 10 weeks after SBRT due to metastatic progression

None