Fig. 1

Total tumour volume (a) and corresponding radiotherapy treatment plans (b) in a patient with mediastinal lymph node metastases and a single pulmonary lesion from metastatic laryngeal cancer. a: All tumour sites were analysed volumetrically via tumour segmentations in all patients to obtain total tumour volumes at diagnosis of oligometastatic disease. Left: 3D rendering showing segmented mediastinal lymph node metastases and a single right-upper lobe metastasis (red). Right: Axial and sagittal view of segmented lymph node metastases. b: Radiotherapy treatment plan showing isodoses (red: 95%, orange: 90%, yellow: 80%, green: 60%, cyan: 40% and blue: 30%) and planning target volumes of stereotactic body radiotherapy to the right-upper lobe metastasis (12 × 6 Gy) as well as of conventionally fractionated chemoradiation (25 × 1.8 Gy + 12 × 1.8 Gy Boost [not shown]) of mediastinal lymph node metastases