Fig. 6
From: Biologically consistent dose accumulation using daily patient imaging
Uncertainty assessment for case 3) in standard fractionation. Top left: Difference of bEQDd − Da as depicted in Fig. 3; note that the scaling was changed in order to allow comparison with the bottom row. Top right: Change in bEQDd induced by changing the underlying assigned α/β-values of the tissues from their standard values here to extreme values, as indicated. Note that when increasing α/β, bEQDd decreases (getting closer to Da), while decreasing α/β (as in case of the rectum (pink) in this example), bEQDd will be higher (larger difference to Da). As can be seen in comparison of bladder (yellow) and CTV (red), the magnitude of difference caused by a change in α/β also depended on the dose variation magnitude. Both scenarios in the upper row represent systematic differences. Bottom row: Worst case dose difference resulting from a 3 mm image registration error propagated to dose accumulation (Eqs. 13 and 14) for Da (left) and bEQDd (right), respectively. The bottom row is an uncertainty that is not systematic