Fig. 3
From: Biologically consistent dose accumulation using daily patient imaging
Total dose differences between the biologically accumulated dose and the conventionally accumulated dose: bEQDd − Da [Gy] for the nine analyzed patient cases; standard fractionation and calculated with the standard α/β-map with CTV = 1.4 Gy, rectum = 3 Gy, bladder = 5 Gy, all other tissue = 3 Gy. Contours were created by a radiation oncologist on the planning CT. As mathematically predicted, bEQDd was systematically higher than (or equal to) Da. Each picture shows the sagittal slice with the highest dose difference for the respective patient. Cases 1)–6) represent patients treated for prostate carcinoma with the whole prostate marked as CTV; cases 7)–9) show irradiation cases of the prostatic fossa with a slightly lower prescription dose of 2.0 instead of 2.25 Gy. All cases were treated and imaged for 34 fractions. For six of the nine cases (1), 3), 5), 6), 8), 9)), differences were 3.3–4.9 Gy in distinct hot spots with a maximum difference of 4.9 Gy in case 6). Only case 4) showed differences below 1.4 Gy over the entire volume