Fig. 2
From: Biologically consistent dose accumulation using daily patient imaging
Biologically accumulated dose bEQDd(di) for a fictional voxel receiving standard (left) or hypofractionated (right) irradiation with different magnitudes of dose variation. The dose variation magnitude is given as the standard deviation of the fractional doses di in percent with respect to the mean dose d. Note that bEQDd(di) with std(di) = 0% equals Da. Black curves represent the voxel in the respective high dose regions, referring to the prescription dose of 2.25 Gy (34 fractions) and 3.0 Gy (21 fractions). Blue lines represent voxels in the respective fractionated treatment in a medium dose regime, likely to occur in high dose gradients in OARs, of 1.5 Gy or 2.25 Gy. Numbers in the plot are given to show dose difference relative to the 0% dose variation case (Da). For less than 12.5% dose variation, the difference remains below 1 Gy