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Table 8 Summary of the results from the fit of the two normal tissue complication probability models for xerostomia using the bother score. AUC = area under the curve. Response rate is the average of the response rates predicted by the models. OR = Odds ratio. The p value was calculated using the two sample t-test for the patient subgroups above and below the dose threshold (the null hypothesis is that the true mean difference is zero)

From: NTCP modeling and dose–volume correlations for acute xerostomia and dry eye after whole brain radiation

Parameters

Response rate (%)

AUC

Odds ratio

p value

Threshold (Gy)

OR (95% CI)

LKB model

Xerostomia bother score

20.1

0.69

20

5.3 (1.2–22.9)

0.009

Relative seriality model

Xerostomia bother score

20.0

0.68

19

6.8 (1.6–28.4)

0.001