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Table 5 Summary of the parameter values that have been reported by different groups for the LKB model, regarding the endpoint of xerostomia. The difference between the physician-scored (CTCAE) patient-reported (PRO-CTCAE) scoring systems is also indicated. Those model parameter sets were applied on the current dataset and the corresponding AUC, OR (with 95% confidence interval and dose threshold) values were calculated

From: NTCP modeling and dose–volume correlations for acute xerostomia and dry eye after whole brain radiation

Parameters

D50 (Gy)

m

n

AUC

OR (95% CI)|thres

CTCAE

 

Burman et al. [36]

46.0

0.18

0.7

0.53

0.0 (–)|–

Roesink et al. [37]

39.0

0.45

1.0

0.66

5.1 (1.1–23.4)|21

Braam et al. [38]

42.0

0.37

1.0

0.66

8.0 (1.8–35.6)|20

PRO-CTCAE

 

Mavroidis et al. [35]

21.9

0.78

1.0

0.67

5.8 (1.5–23.2)|20