Skip to main content

Table 4 Summary of the results from the fit of the two normal tissue complication probability models for xerostomia and dry eye. AUC = area under the curve. Response rate is the average of the response rates predicted by the models. OR = Odds ratio. Threshold doses refer to gEUD and \(\overline{\overline{D}}\) (for the LKB and RS models, respectively). The p value was calculated using the two sample t-test for the patient subgroups above and below the dose threshold (the null hypothesis is that the true mean difference is zero)

From: NTCP modeling and dose–volume correlations for acute xerostomia and dry eye after whole brain radiation

Parameters

Response rate (%)

AUC

Odds ratio

p value

Threshold (Gy)

OR (95% CI)

LKB model

Xerostomia

34.7

0.67

20

5.6 (1.5–20.6)

0.03

Dry eye

24.1

0.57

27

2.6 (0.6–10.9)

0.09

Relative seriality model

Xerostomia

34.6

0.67

20

5.8 (1.5–23.2)

0.03

Dry eye

24.1

0.56

27

2.6 (0.6–10.9)

0.09