From: Radiotherapeutic treatment options for oligotopic malignant liver lesions
Organ Tissue | TD5/5(1) [Gy] | TD5/5(1/3) [Gy] | TD50/5(1) [Gy] | TD50/5(1/3) [Gy] | σ [Gy] (1) | σ [Gy] (1/3) | n (volume) | m (slope) | α/β [Gy] | Clinical endpoint |
---|---|---|---|---|---|---|---|---|---|---|
Liver | 25 | 50 | 40 | 80 | 10 | 20 | 0.6 | 0.25 | 1.5 | Radiation-induced liver disease (RILD) |
Lung | 18 | 45 | 25 | 74 | 12 | 15 | 0.9 | 0.2 | 2.5 | Pulmonary dysfunction |
Kidney | 23 | 50 | 28 | 65 | 3 | 6.5 | 0.7 | 0.1 | 0.5–4 | Nephropathy/renal failure |
Small bowel | 40 | 50 | 55 | 70 | 10 | 14 | 0.1–0.2 | 0.2 | 3–5 | Obstruction/perforation |
Stomach | 45 | 54 | 60 | 76 | 10 | 11 | 0.1–0.2 | 0.15 | 5 | Bleeding/ulcer |
Brain | 45 | 60 | 60 | 86 | 12 | 17 | 0.2–0.3 | 0.2 | 2 | Necrosis/cognitive dysfunction |
Heart | 15 | 18 | 29 | 35 | 12 | 14 | 0.16 | 0.4 | 3 | Cardiac mortality |
Skin | 55 | 65 | 65 | 79 | 6.5 | 8 | 0.06–0.16 | 0.1 | 1–4 | Fibrosis/ulcer/Teleangiectasia |
Spinal cord | 47 | 50 | 70 | 74 | 14 | 15 | 0.05 | 0.2 | 2.5–5 | Myelopathy |
Nerves Plexus | 60 | 62 | 100 | 104 | 30 | 31 | 0.03 | 0.3 | 1.5–3.5 | Neuropathy/plexopathy |