Clinical outcomes of extensive-stage small cell lung cancer patients treated with thoracic radiotherapy at different times and fractionations

Table 4 Adverse events summarized by the time and dose of TRT

Toxic Effect/Grade	≤ 2 cycles	3–4 cycles	5–6 cycles	> 6 cycles	p value	Low-dose	High-dose	p value
Haematologic toxicity grade ≥ 2
Leucopenia	27	52	49	18	0.244	90	56	0.159
Anemia	9	10	7	6	0.111	20	12	0.734
Thrombocytopenia	7	12	14	5	0.994	24	14	0.778
Nausea/vomiting
Grade 0–1	33	62	79	24		137	61
> Grade 2	8	16	13	9	0.388	22	24	0.006
TRT-induced Oesophagitis
Grade 0–1	37	71	83	29		148	72
> Grade 2	4	7	9	4	0.729	11	13	0.036
TRT-induced Pneumonitis
Grade 0–1	35	64	77	25		133	68
> Grade 2	6	14	15	8	0.714	26	17	0.476

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