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Table 1 Basic characteristics of included studies

From: Can internal mammary lymph nodes irradiation bring survival benefits for breast cancer patients? A systematic review and meta-analysis of 12,705 patients in 12 studies

References

Country

Design

Recruitment period

Number of patients

Inclusion criteria

HR (lower CI-upper CI)

Follow-up time (month)

IMNI

Non-IMNI

OS

DFS

Wang [13]

China

RCS

2007–2010

390

482

pBC

0.82 (0.59–1.15)

0.54 (0.41–0.72)

98

Luo [14]

China

RCS

2005–2013

236

261

Stage II–III

0.62 (0.37–1.03)

0.65 (0.46–0.93)

64

Thorsen [15]

Denmark

PCS

2003–2007

1492

1597

N + 

0.82 (0.72–0.94)

107

Kim [16]

Korea

RCS

2001–2009

284

237

Stage II–III

0.51 (0.26–1.01)

0.58 (0.34–1.00)

71

Yadav [17]

India

RCS

1978–1996

153

166

Stage II–III

0.89 (0.60–1.30)

0.35 (0.22–0.55)

203

Aleknavičius [18]

Lithuania

RCS

1987–1997

165

268

Tumor in central/medial

0.75 (0.55–1.01)

0.67 (0.46–0.99)

102

Courdi [19]

France

RCS

1975–2008

489

1141

N − 

0.99 (0.81–1.22)

1.04 (0.88–1.23)

154

Chang [20]

Korea

RCS

1994–2002

197

199

Stage II–III

0.91 (0.64–1.28)

0.7 (0.52–0.96)

98

Hennequin [21]

France

RCT

1991–1997

672

662

N + 

Tumor in central/medial

0.95 (0.80–1.13)

103

Olson [22]

Canada

RCS

2001–2006

1000

1413

N + 

T3/4N0

0.95 (0.78–1.15)

74

Stemmer [23]

Israel

NRCT

1994–1998

67

33

Stage II–III

0.48 (0.19–1.21)

0.44 (0.18–1.08)

77

Obedian [24]

America

RCS

1970–1990

535

411

Breast conservation surgery

1.56 (1.10–2.22)

156

  1. RCS retrospective cohort study, PCS prospective cohort study, NRCT non-randomized controlled trial, RCT randomized controlled trial