Table 2 Toxicities of radiotherapy

Aghi et al. [44]

8

NR

60.2^†

59.4–61.2

1.5–1.8

Grade 4 radiation necrosis (n = 1)

Komotar et al. [9]

13

NR

59.4

NR

1.8–2.0

Grade 1–2 skin dermatitis, erythema, alopecia, fatigue, and headache (NR)

Park et al. [10]

17 + 10*

Conventional RT/ 3D-CRT

61.2

40.0–61.2

NR (30–35)

Grade 1–2 fatigue, headache, nausea, dizziness, skin irritation (NR)

Aizer et al. [11]

18 + 12*

NR

60.0

55.8–64.0

NR

Grade 4 radiation related glioblastoma (n = 1)

Sun et al. [45]

39

NR

53.8

46.0–60.0

1.7–2.0

Grade 1–2 radiation necrosis (n = 1)

Grade 4 radiation necrosis (n = 3)

Wang et al. [26]

3 + 9*

NR

NR

54.0–60.0

NR (27–30)

Grade 1–2 headache, dizziness, and skin irritation (NR)

Bagshaw et al. [13]

12 + 9*

NR

54.0

45.0–59.4

NR

Grade 1 fatigue, headache, and seizure (n = 4)

Grade 2 headache, dizziness, alopecia, and hearing and memory impairment (n = 4)

Grade 3 radiation necrosis (n = 2)

Grade 4 optic nerve disorder (n = 1)

Graffeo et al. [14]

8

NR

54.0

50.5–61.2

NR (28–30)

Undetermined grade major morbidity (n = 1)

Dohm et al. [34]

12 + 51*

3D-CRT

55.7

50.4–59.4

NR (28–35)

Grade 4 seizure (n = 1)

Grade 3 radiation necrosis, cognitive disturbance, peripheral neuropathy, seizure, aphasia, and optic nerve disorders (n = 7)

Cho et al. [33]

13 + 21*

Conventional RT

NR

30.0–61.2

NR (30–35)

Grade 1–2 fatigue, headache, nausea, dizziness, and skin irritation (NR)

Shakir et al. [36]

12 + 3*

3D-CRT

54.0

52.2–59.4

1.8

Grade 1–2 headache, dizziness, and paresthesia (n = 8)

Lee et al. [16]

20 + 33*

3D-CRT/IMRT

50.4/54.0

36.0–64.0/50.4–59.4

1.8–2.0

Grade 1 radiation necrosis (n = 2)

Ros-Sanjuan et al. [38]

5 + 8*

3D-CRT

NR

NR

NR

Undetermined grade radiation necrosis (n = 1)