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Table 3 Main toxicity and cosmetic outcomes (fair/poor)

From: A meta-analysis of the efficacy and safety of accelerated partial breast irradiation versus whole-breast irradiation for early-stage breast cancer

Author/year

Group

Cosmetic outcome (fair/poor)

Induration or

Fibrosis Grad ≥ 2

Telangie-ctasia

Grad ≥ 2

Breast pain

Grad ≥ 2

Fatty necrosis

Grade ≥ 2

Acute Skin toxicity Grade ≥ 2

Late skin toxicity

Grade ≥ 2

Acute toxicity

Late

toxicity

CTCAE

/RTOG Grade ≥ 2

Acute pneumonitis

Grade ≥ 2

Physician-rated

Self-rated

Vicini 2019 [17]

APBI

WBI

          

54.2%

66.1%

 

Whelan2019 [18]

APBI

WBI

32%

16%(5-years)

30%

18%(5-years)

22.9%

4.6%

9.3%

3.7%

4.8%

1.9%

2.7%

 < 0.5%

  

9.5%

30.8%

32.3%

13.3%

  

Strnad 2016 [19,20,21,22]

APBI

WBI

7%

10%(5-years)

8%

9%(5-years)

6.4%

4.6%

4.1%

4.6%

8.4%

11.9%

1.4%

1%

2.2%

43.5%

3.92%

6.1%

    

Livi 2015 [27, 28]

APBI

WBI

0%

0.8%

     

1.9%

37.7%

0%

0.8%

    

Vaidya 2014 [29, 30]

APBI

WBI

       

0.23%

0.75%

(Grade3/4)

  

3.3%

3.9%

(Grade3/4)

 

Polgár 2013 [31]

APBI

WBI

19.2%

37.1%

           

Veronesi 2013 [32]

APBI

WBI

     

4.74%

2.43%

1.08%

7.77%

(Any acute)

1.29%

1.21%

(Any chronic)

    

Rodriguez 2013 [33]

APBI

WBI

 

0%

0%

    

17.6%

74.5%

0%

0%

   

0%

A single case

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Radiation Oncology

ISSN: 1748-717X

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