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Table 2 Main long-term outcomes

From: A meta-analysis of the efficacy and safety of accelerated partial breast irradiation versus whole-breast irradiation for early-stage breast cancer

Author/year

Group

5–8–10–12 year DFS

5–8–10–12 year

OS

5–8–10–12 year

LR

5–8–10 year

NR

Breast cancer deaths

Distant metastasis

Contralateral breast cancer

Second primary cancers

Jayant 2020 [23]

APBI

WBI

NR

96.70%/–/88.62%/83.13%

97.69%/–/87.77%/84.72%

3.96%/–/7.2%/7.2%

1.05%/–/2.8%/3.5%

NR

3.61%

3.0%

1.0%

1.4%

NR

NR

Vicini 2019 [24]

APBI

WBI

–/–/78.1%/–

–/–/79.7%/–

–/–/90.6%/–

–/–/91.3%/–

–/–/4.6%/–

–/–/3.9%/–

NR

2.3%

2.2%

2.4%

3.1%

3.0%

3.5%

9%

10%

Whelan 2019 [18]

APBI

WBI

96.4%/94.9%/–/

96.8%/95.4%/–/

96.2%/93.6%/–/–

97%/94.3%/–/–

2.3%/3%/–/–

1.7%/2.8%/–/–

–/0.4%/–

–/0.2%/–

1.7%

1.5%

1.9%

1.7%

2.7%

3.6%

10.6%

9.0%

Coles 2017 [25, 26]

APBI

WBI

NR

NR

0.5%/–/–/–

1.1%/–/–/–

0.3%/–/–

0.1%/–/–

1.5%

1.3%

1.8%

1.9%

1.9%

1.8%

5.5%

7.0%

Strnad 2016 [19,20,21,22]

APBI

WBI

95.03%/–/–/–

94.45%/–/–/–

97.27%/–/–/–

95.55%/–/–/–

1·44%/–/–/–

0·92%/–/–/–

0.47%/–/–

0.18%/–/–

0.6%

0.7%

0.8%

0.9%

0.8%

0.9%

5.5%

4.0%

Livi 2015 [27, 28]

APBI

WBI

NR

99.4%/–/–/–

96.6%/–/–/–

1.5%/–/–/–

1.4%/–/–/–

1.5%/–/–

1.9%/–/–

0.4%

1.2%

1.2%

1.5%

1.2%

2.7%

NR

Vaidya 2014 [29, 30]

APBI

WBI

NR

NR

3.3%/–/–/–

1.3%/–/–/–

0.5%/–/–

0.3%/–/–

1.2%

0.9%

0.5%

0.4%

NR

NR

Polgár 2013 [31]

APBI

WBI

88.8%/–/85.3%/–

90.5%/–/83.6%/–

–/–/79.7%/–

–/–/82.1%/–

4.0%/–/5.9%/–

3.3%/–/5.1%/–

1.6%/–/2.5%

1.7%/–/1.7%

NR

5.5%

8.5%

7.0%

6.2%

12.5%

10.8%

Veronesi2013 [32]

APBI

WBI

NR

96.8%/–/–/–

96.9%/–/–/–

4.4%/–/–/–

0.4%/–/–/–

1.0%/–/–

0.3%/–/–

3.5%

3.1%

5.1%

5.4%

1.2%

2.0%

4.3%

5.4%

Rodriguez 2013 [33]

APBI

WBI

NR

NR

0%/–/–/–

0%/–/–/–

0%/–/–

0%/–/–

0%

0%

0%

0%

NR

5.5%

7.0%

  1. OS overall survival, DFS disease-free survival, LR local recurrence, RR regional recurrence, NR no reported, Adverse cosmesis physician-scored cosmetic results fair and poor, Second primary cancers had a second primary tumor in the contralateral-breast or a second tumor at a site other than the breast