Table 1 The main detailed characteristics of the included studies
Author/year | Follow-up (years) | Study Period | Sample Size (n, APBI/WBI) | Jadad score | Age (years) | Stage | Receptor status | Premen-opausal | Histology | Treatment arms |
|---|---|---|---|---|---|---|---|---|---|---|
Jayant 2020 [23] | 9 | 2004–2012 | 581/572 | 5 | 63 | 0 ~ II | ER + :98% HER2 + :5.5% | NR | Grade 3: 5.6% IDC:100% | APBI: 50 kV energy X-rays IORT 20 Gy WBI:EBRT40–56 Gy/15–25F ± boost10–16 Gy/5–8F |
Vicini 2019 [24] | 10.2 | 2005–2013 | 2036/2089 | 5 | 54 | 0 ~ II | ER + :81% HER2 + :NR | 39% | Grade 3: 26.8% DCIS: 24.5% | APBI: HDR brachytherapy 34 Gy or 3DCRT 38.5 Gy/10F, BID WBI: EBRT 50 Gy/25F ± Boost 10 Gy/5 F at least |
Whelan 2019 [18] | 8.6 | 2006–2011 | 1070/1065 | 5 | 61 | 0 ~ II | ER + :90% HER2 + :4.7% | NR | Grade 3: 12.9% DCIS: 18% | APBI: 3DCRT or IMRT 38.5 Gy/10F,BID WBI: External beam 42.5 Gy/16F or 50 Gy/25F ± Boost 10 Gy/5F |
6.1 | 2007–2010 | 669/674 | 5 | 62 | I ~ II | ER + : 95.1% HER2 + : 4% | NR | Grade 3: 9.5% IDC: 85.4% | APBI: IMRT 40 Gy/15F WBI: IMRT 40 Gy/15F | |
Strnad 2016 [19] | 6.6 | 2004–2009 | 633/551 | 7 | 62 | 0 ~ IIA | ER + :91.4% HER2 + :NR | 16.9% | Grade 3: 8.4% IDC: 74.1% | APBI: HDR brachytherapy 32 Gy/8F or 30.1 Gy/7F BID PDR brachytherapy 50 Gy/0.6–0.8 Gy/per h pulses,24 h/day WBI: (4–10MV) photon beams 50.0–50.4 Gy /25–28F ± Boost 10 Gy/5F |
5 | 2005–2013 | 260/260 | 5 | 60–69 | I ~ II | ER + : 95.4% HER2 + :3.6% | NR | Grade 3:11.4% IDC: 57.5% DCIS: 10.6% | APBI: IMRT 30 Gy/5F WBI: IMRT 50 Gy/25F + Boost 10 Gy/5F | |
2.4 | 2000–2002 | 1679/1696 | 5 | 61–70 | I ~ IIIA | ER + :93% HER2 + :11.6% | NR | Grade 3: 15.2% IDC: 100% | APBI: 50 kV energy X-rays IORT 20 Gy WBI: EBRT40–56 Gy/15–25F ± boost10–16 Gy/5–8F | |
Polgár 2013 [31] | 10.2 | 1998–2004 | 128/130 | 4 | 58.5 | I ~ II | ER + :88.7% HER2 + :NR | 21.3% | Grade 3: 0% IDC: 81.8 | APBI: HDR brachytherapy 36.4 Gy/7F, BID; Protocol allowed 50 Gy limited field electron beam if patients unsuitable for brachytherapy WBI: Telecobalt or 6–9MV photon beams using wedged tangential fields 42–50 Gy/2 Gy per day |
Veronesi2013 [32] | 5.8 | 2000–2007 | 651/654 | 5 | 60–69 | I ~ II | ER + : 90.8% HER2 + :3.4% | NR | Grade 3: 21.7% IDC: 80.2% | APBI: Electron IORT 21 Gy WBI: EBRT 50 Gy/25F + Boost 10 Gy/5F |
Rodriguez 2013[33] | 5 | NR | 51/51 | 4 | 68.6 | I ~ II | ER + : 98% HER2 + : 1% | 0% | Grade 3: 0% ILC excluded | APBI: 3DCRT 37.5 Gy/10F,BID WBI: 3DCRT 48 Gy/24F ± Boost 10 Gy/5F |