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Table 2 One-way and full sensitivity analyses performed as part of the cost-effectiveness evaluation

From: Individualized quality of life benefit and cost-effectiveness estimates of proton therapy for patients with oropharyngeal cancer

Component Base case Variation in sensitivity analysis
One-way sensitivity analysis   
 Proportion of chronic dysphagia 50% chronic, 50% resolved within 5 years Scenario 1: 0% chronic, 100% resolved within 5y
Scenario 2: 100% chronic, 0% resolved within 5y
 Cost of proton therapy (33 fx) $36,659 Scenario 1: $31,659
Scenario 2: $26,659
Scenario 3: $21,659
Full sensitivity analysis   
 QALY calculation   
  Hazard ratio for patients with > 10   pack-year smoking history 1.73 Normal distribution matching 95% CI 1.17–2.57
  Quality-adjustment factors   Beta distributions matching 95% CIs:
  Dysphagia (grade ≥ 2) 0.83 0.70–0.93
  Esophagitis (grade ≥ 3) 0.66 0.35–0.90
  Xerostomia (grade ≥ 2) 0.82 0.72–0.90
  Hypothyroidism (elevated TSH with or without T4/T3 changes requiring hormone replacement) 0.97 0.94–0.98
  Oral mucositis (grade ≥ 3) 0.06 0.01–0.15
 Cost-effectiveness calculation   
  Proportion of oral mucositis or esophagitis cases requiring inpatient hospital admission 10% Normal distribution matching 95% CI 0–20%
  Proportion of oral mucositis cases resulting in emergency room visit 15% Normal distribution matching 95% CI 5–25%
  Proportion of esophagitis cases resulting in emergency room visit 10% Normal distribution matching 95% CI 0–20%
  Proportion of dysphagia cases requiring chronic PEG tube 10% Normal distribution matching 95% CI 0–20%
  Proportion of patients receiving stricture dilation for dysphagia 16% Normal distribution matching 95% CI 11–21%
  Cost of stricture dilation $1700 Normal distribution matching 95% CI $1200–$2200
  1. More information about the components used in the quality-adjusted life years calculation can be found in ref [12]