Table 1 The management and patient procedures related to the different normal tissue complications, as well as the estimated total cost of the different parts of managing the complications or the cost of the related patient procedure

Oral mucositis (grade ≥ 3) or Esophagitis (grade ≥ 3)

Fentanyl 25 μg/h patch (for 6 weeks)

$168.8

NADAC database

Percocet 325 mg tablet (for 6 weeks)

$1514.1

NADAC database

Mucositis cocktail (for 6 weeks)

$37.0

NADAC database

Weekly IV hydration (for 4 weeks)

$154.2

2019 Medicare Coding and Payment Report

PEG tube placement in 30% of cases

$5686*

Callahan et al. [18]

Emergency room visit in 15% of cases for oral mucositis and 10% of cases for esophagitis

$2096

2018 Health Care Cost and Utilization Report^†

In patient hospitalization in 10% of cases

$19,672

2018 Health Care Cost and Utilization Report

Loss of 1 month of work

$2718

US Census Bureau Median per Capita Income 2014–2018^‡

Dysphagia (grade ≥ 2)

Chronic PEG tube in 10% of cases

$18,836/year*

Callahan et al. [18]

Stricture dilation in 16% of patients [14, 15]

$1700 (based on average Medicare charges ranging from $1200 to $2200)

www.howmuchisit.org/esophageal-dilation-cost/ (updated Aug 2018)

Hypothyroidism (elevated TSH with or without T4/T3 changes requiring hormone replacement)

Levothyroxine hormone replacement

$174.2/year (assuming 70 kg body weight)

NADAC database

Xerostomia (grade ≥ 2)

Pilocarpine 5 mg (for 10 weeks)

$231

NADAC database

Cevimeline 30-45 mg (for 6 weeks)

$251.4