Correlation of dosimetric factors with the development of symptomatic radiation pneumonitis in stereotactic body radiotherapy

Table 6 Dose Volume Histogram Characteristics (Cubic centimeters of Lung Exposed)

Characteristic	No Radiation Pneumonitis (n = 85)	Symptomatic Radiation Pneumonitis (n = 8)	P value
Contralateral Lung V5, cm3
Median	54	131	0.30
Range	0–532	25–649	0.30
Ipsilateral Lung V30, cm3
Median	58	127	0.02
Range	14–331	49–153	0.02
Ipsilateral Lung V40, cm3
Median	36	80	0.06
Range	9–198	23–106	0.06
Total Lung V5, cm3
Median	513	701	0.04
Range	141–1308	549–2027	0.04
Total Lung V10, cm3
Median	291	468	0.01
Range	64–856	357–1129	0.01
Total Lung V12.4, cm3
Median	223	372	0.004
Range	47–789	311–932	0.004
Total Lung V13.5, cm3
Median	195	333	0.004
Range	41–735	283–829	0.004
Total Lung V15, cm3
Mean	171	311	0.003
Range	36–706	250–712	0.003
Total Lung V20, cm3
Mean	113	226	0.01
Range	24–567	125–422	0.01
Total Lung V25, cm3
Mean	79	169	0.01
Range	18–436	75–291	0.01
Total Lung V30, cm3
Mean	59	130	0.01
Range	13–332	49–215	0.01
Total Lung V40, cm3
Mean	36	81	0.02
Range	9–199	23–135	0.02

Abbreviations: V_dose is the percent of lung receiving greater than the “dose” (in Gy). Symptomatic Radiation Pneumonitis = RTOG G3+ or CTCAE G2–3+ RP
P-values from Wilcoxon Rank Sum tests, with all values Bonferroni adjusted
Bolded P-values indicate statistical significance

ISSN: 1748-717X