Table 1 Select Patient and Tumor Characteristics
Characteristic | No Radiation Pneumonitis (n = 85) | Symptomatic Radiation Pneumonitis (n = 8) | P value |
|---|---|---|---|
Age, years | |||
 Median | 73.5 | 72.4 | 0.56†|
 Range | 10.1–89.2 | 50.4–79.8 | |
Tumor size, cma | |||
 Median | 1.8 | 3.4 | 0.002†|
 Range | 0.6–4.0 | 1.7–5.3 | |
T stagea | |||
 T1 (%) | 73 (94.8%) | 2 (33.3%) | 0.001 |
 T2 (%) | 4 (5.2%) | 4 (66.7%) | |
Radiation Dose | |||
 50/5 (%) | 57 (67.1%) | 6 (75.0%) | 0.004 |
 48/4 (%) | 26 (30.1%) | 0 (0.0%) | |
 60/5–8 (%) | 2 (2.4%) | 2 (25.0%) | |
Treatment year | |||
 2010 | 1 (1.2%) | 0 (0.0%) | 0.86 |
 2011 | 7 (8.2%) | 0 (0.0%) | |
 2012 | 9 (10.6%) | 0 (0.0%) | |
 2013 | 10 (11.8%) | 0 (0.0%) | |
 2014 | 7 (8.2%) | 1 (12.5%) | |
 2015 | 19 (22.4%) | 2 (25.0%) | |
 2016 | 24 (28.2%) | 4 (50.0%) | |
 2017 | 8 (9.4%) | 1 (12.5%) | |
Race | |||
 Black (%) | 9 (10.6%) | 0 (0.0%) | 1.000 |
 White (%) | 74 (87.1%) | 8 (100.0%) | |
 Other (%) | 2 (2.4%) | 0 (0.0%) | |
Sex | |||
 Female (%) | 49 (57.6%) | 6 (75.0%) | 0.46 |
 Male (%) | 36 (42.4%) | 2 (25.0%) | |
Smoking status (missing = 11) | |||
 Not smoking (%) | 23 (30.2%) | 4 (66.7%) | 1.000 |
 Current smoker (%) | 53 (69.7%) | 2 (33.3%) | |
Pack years | |||
 Median | 40 | 27.5 | 0.25 |
 Range | 0–180.0 | 0–82.5 | |
ECOG Performance status | |||
 0 (%) | 25 (29.4%) | 2 (25.0%) | 0.82 |
 1 (%) | 43 (50.6%) | 4 (50.0%) | |
 2 (%) | 15 (17.7%) | 2 (25.0%) | |
 3 (%) | 2 (2.4%) | 0 (0.0%) | |
Sitea | |||
 RUL (%) | 21 (26.9%) | 0 | 0.06 |
 RML (%) | 5 (6.4%) | 0 | |
 RLL (%) | 23 (29.5%) | 2 (33.3%) | |
 LUL (%) | 18 (23.1%) | 1 (16.7%) | |
 LLL (%) | 11 (14.1%) | 2 (33.3%) | |
 Liver (%) | 0 (0.0%) | 1 (16.7%) | |
Histology | |||
 Adenocarcinoma (%) | 36 (42.4%) | 3 (37.5%) | 0.87 |
 Squamous cell carcinoma (%) | 25 (29.4%) | 3 (37.5%) | |
 No biopsy (%) | 9 (10.6%) | 1 (12.5%) | |
 Metastatic non-lung primary (%) | 6 (7.1%) | 1 (12.5%) | |
 NOS/other (%) | 8 (9.4%) | 0 (0.0%) | |
 SCLC (%) | 1 (1.2%) | 0 (0.0%) | |
Prior Radiation to Lung | |||
 Yes, SBRT (%) | 11 (12.9%) | 1 (12.5%) | 0.27 |
 Yes, CCRT (%) | 6 (7.1%) | 2 (25.0%) | |
 Yes, Mantle field (%) | 1 (1.2%) | 0 (0.0%) | |
 No (%) | 67 (78.8%) | 5 (62.5%) | |
Two lesions treated simultaneously | |||
 Yes (%) | 8 (11.5%) | 2 (25.0%) | 0.21 |
 No (%) | 77 (88.5%) | 6 (75.0%) | |