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Table 2 The constraints evaluation of ipsilateral lung, contralateral breast and heart of all plans stratified by different breast sizes. L large breast size (n = 18), M medium breast size (n = 52), S small breast size (n = 29)

From: Automated Hypofractionated IMRT treatment planning for early-stage breast Cancer

 Manual (Mean value ± SD)Auto (Mean value ± SD)
ParameterLMSp-valueLMSp-value
Ipsilateral lung
 V16Gy[%]12.9 ± 3.814.5 ± 3.613.7 ± 3.50.2513.0 ± 3.513.5 ± 3.313.1 ± 2.20.78
 V4Gy[%]28.1 ± 6.929.7 ± 5.825.7 ± 3.7< 0.0128.8 ± 7.028.4 ± 5.226.8 ± 2.40.30
Contralateral breast
 V5Gy[%]0.0 ± 0.00.3 ± 1.70.0 ± 0.40.460.0 ± 0.00.8 ± 3.40.0 ± 0.00.23
 Max[Gy]2.0 ± 2.34.7 ± 9.62.2 ± 2.60.193.6 ± 4.46.6 ± 11.32.8 ± 2.90.13
Heart
 V20Gy[%]0.9 ± 1.40.9 ± 1.30.9 ± 1.20.981.2 ± 1.50.9 ± 0.90.9 ± 1.10.42
 Mean[Gy]1.5 ± 0.61.4 ± 0.61.3 ± 0.70.371.7 ± 0.71.4 ± 0.51.2 ± 0.50.03