Table 2 Univariate analysis of clinical factors in predicting failure pattern
Characteristic | Local failure (n = 46) | Distant failure (n = 54) | Chi-square test P value | FDR correction Q value |
|---|---|---|---|---|
Sex | 0.035 | 0.093 | ||
Female | 5 (25.0%) | 15 (75.0%) | ||
Male | 41 (51.2%) | 39 (48.8%) | ||
Smoking | 0.027 | 0.093 | ||
No | 13 (32.5%) | 27 (67.5%) | ||
Yes | 33 (55.0%) | 27 (45.0%) | ||
Pathology | 0.031 | 0.093 | ||
Squamous cell carcinoma | 24 (61.5%) | 15 (38.5%) | ||
Non-small cell carcinoma | 3 (25.0%) | 9 (75.0%) | ||
Adenocarcinoma | 19 (38.8%) | 30 (61.2%) | ||
Tumor diameter | 0.284 | 0.432 | ||
≤3 cm | 13 (37.1%) | 22 (62.9%) | ||
> 3 cm, ≤5 cm | 20 (55.6%) | 16 (44.4%) | ||
> 5 cm, ≤7 cm | 10 (52.6%) | 9 (47.4%) | ||
> 7 cm | 3 (30.0%) | 7 (70.0%) | ||
Location | 0.012 | 0.093 | ||
Central | 25 (61.0%) | 16 (39.0%) | ||
Peripheral | 21 (35.6%) | 38 (64.4%) | ||
EGFR | 0.018 | 0.093 | ||
Wild | 40 (52.6%) | 36 (47.4%) | ||
Mutant | 6 (25%) | 18 (75%) | ||
Clinical T stage | 0.260 | 0.432 | ||
cT1 | 10 (32.3%) | 21 (67.7%) | ||
cT2 | 18 (54.5%) | 15 (45.5%) | ||
cT3 | 11 (55.0%) | 9 (45.0%) | ||
cT4 | 7 (43.8%) | 9 (56.3%) | ||
Clinical N stage | 0.297 | 0.432 | ||
cN0–1 | 5 (71.4%) | 2 (28.6%) | ||
cN2 | 25 (47.2%) | 28 (52.8%) | ||
cN3 | 16 (40.0%) | 24 (60.0%) | ||
Clinical TNM stage | 0.267 | 0.432 | ||
cIIIA | 19 (52.8%) | 17 (47.2%) | ||
cIIIB | 23 (39.7%) | 35 (60.3%) | ||
cIIIC | 4 (66.7%) | 2 (33.3%) | ||
Sequence of CRT | 0.566 | 0.604 | ||
Concurrent | 17(37.0%) | 29(63.0%) | ||
Sequential | 23(42.6%) | 31(57.4%) | ||
Consolidation chemotherapy | 0.087 | 0.199 | ||
No | 22(38.6%) | 35(61.4%) | ||
Yes | 24(55.8%) | 19(44.2%) | ||
Radiation Dose | 0.405 | 0.498 | ||
< 60 Gy | 5 (35.7%) | 9 (64.3%) | ||
≥60 Gy | 41 (47.7%) | 45 (52.3%) | ||
*Age (y) (continuous variable) | m#61.5(38–83) | m#59(22–73) | 0.026 | 0.093 |
*Primary tumor volume (cm3) | m#47.04(5.12–383.14) | m#38.17(0.89–392.9) | 0.377 | 0.498 |
*Lymph nodal volume (cm3) | m#62.68(0–241.92) | m#65.69(0–335.86) | 0.966 | 0.966 |
*Total volume (cm3) | m#142.84(19.79–473.64) | m#129.58(27.25–481.28) | 0.487 | 0.557 |