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Table 9 Patient’s characteristics according to age groups

From: Optimal radiotherapy for patients with internal mammary lymph node metastasis from breast cancer

Characteristics

Number of patients (%)

p-value

≤ 40 years

(n = 38)

>  40 years(n = 46)

Follow-up duration

Median months (range)

58.5 mo (15–111)

59.0 mo (12–104)

0.215 1)

Histologic grade

1–2

22 (57.9%)

23 (50.0%)

0.163

3

10 (26.3%)

20 (43.5%)

Subtypes

Non-TNBC

25 (65.8%)

29 (63.0%)

0.974

TNBC

13 (34.2%)

17 (37.0%)

cT stages

1–2

27 (71.1%)

28 (60.9%)

0.916

3–4

11 (28.9%)

18 (39.1%)

cN stages

2b or 3b

27 (71.1%)

36 (78.3%)

0.613

3c

11 (28.9%)

10 (21.7%)

FNABx for IMN

(−) or unknown

16 (42.1%)

28 (60.9%)

0.135

(+)

22 (57.9%)

18 (39.1%)

Extent of the IMN

Single ICS

18 (47.4%)

19 (41.3%)

0.737

Multiple ICS

20 (52.6%)

27 (58.7%)

IMN long diameter

<  1.0 cm

20 (52.6%)

22 (47.8%)

0.826

≥ 1.0 cm

18 (47.4%)

24 (52.2%)

Neoadjuvant chemotherapy

Not done

7 (18.4%)

11 (23.9%)

0.731

Done

31 (81.6%)

35 (76.1%)

Primary surgery

BCS

20 (52.6%)

20 (43.5%)

0.538

Mastectomy

18 (47.4%)

26 (56.5%)

Axillary surgery

ALND

32 (84.2%)

42 (91.3%)

0.509

SLNB

6 (15.8%)

4 (8.7%)

RT dose to IMN 2)

50–63.5 Gy

15 (39.5%)

20 (43.5%)

0.882

63.6–70.4 Gy

23 (60.5%)

26 (56.5%)

  1. 1)By the Mann-Whitney U-test
  2. 2)Radiotherapy dose was calculated using the biologically equivalent dose in 2 Gy fractions (EQD2) assuming the α/β ratio of 3.5 Gy
  3. Abbreviations: mo Months, TNBC Triple-negative breast cancer, IMN Internal mammary node, FNABx Fine needle aspiration biopsy, ICS Intercostal space, BCS Breast conserving surgery, ALND Axillary lymph node dissection, SLNB Sentinel lymph node biopsy