Table 7 Prognostic factors of overall survival
From: Optimal radiotherapy for patients with internal mammary lymph node metastasis from breast cancer
Characteristics | 5-year OS | Univariate p-value | Multivariate p-value | HR (95% CI) | |
|---|---|---|---|---|---|
Age | ≤40 years (n = 38) | 94.6% | 0.007 | 0.009 | 0.132(0.029–0.609) |
> 40 years (n = 46) | 75.4% | ||||
Tumor subtype1) | Non-TNBC (n = 54) | 92.0% | 0.016 | 0.003 | 0.167(0.051–0.548) |
TNBC (n = 30) | 70.0% | ||||
cT stages | 1–2 (n = 47) | 87.0% | 0.232 | 0.067 | 3.049(0.925–10.054) |
3–4 (n = 37) | 80.1% | ||||
cN stages | 2b or 3b (n = 63) | 83.3% | 0.492 | – | – |
3c (n = 21) | 85.7% | ||||
Malignant cells on FNABx of the IMN | (−) or unknown (n = 44) | 84.5% | 0.557 | – | – |
(+) (n = 40) | 83.4% | ||||
Extent of IMN | Single ICS (n = 37) | 89.1% | 0.045 | 0.845 | 0.890(0.275–2.880) |
Multiple ICS (n = 47) | 79.9% | ||||
IMN long diameter | < 1.0 cm (n = 42) | 92.7% | 0.053 | 0.052 | 1.621(0.318–8.255) |
≥1.0 cm (n = 42) | 75.7% | ||||
Neoadjuvant chemotherapy | Performed (n = 66) | 82.9% | 0.493 | – | – |
Not performed (n = 18) | 87.8% | ||||
Axillary surgery | ALND (n = 74) | 83.2% | 0.556 | – | – |
SLNB (n = 10) | 90.0% | ||||
EQD2 of the IMN2) | 50.0–63.5 Gy (n = 35) | 85.3% | 0.926 | – | – |
63.6–70.4 Gy (n = 49) | 82.8% | ||||