Table 6 Prognostic factors of locoregional-recurrence free survival
From: Optimal radiotherapy for patients with internal mammary lymph node metastasis from breast cancer
Characteristics | 5-year LRRFS | Univariate p-value | Multivariate p-value | HR (95% CI) | |
|---|---|---|---|---|---|
Age | ≤40 years (n = 38) | 94.7% | 0.184 | 0.187 | 0.397(0.010–1.564) |
> 40 years (n = 46) | 84.3% | ||||
Tumor subtype1) | Non-TNBC (n = 54) | 96.3% | 0.009 | 0.004 | 0.120(0.029–0.500) |
TNBC (n = 30) | 75.8% | ||||
cT stages | 1–2 (n = 47) | 87.1% | 0.568 | – | – |
3–4 (n = 37) | 91.7% | ||||
cN stages | 2b or 3b (n = 63) | 88.7% | 0.915 | – | – |
3c (n = 21) | 90.2% | ||||
Malignant cells on FNABx of the IMN | (−) or unknown (n = 44) | 89.8% | 0.961 | – | – |
(+) (n = 40) | 88.5% | ||||
Extent of IMN | Single ICS (n = 37) | 89.0% | 0.660 | – | – |
Multiple ICS (n = 47) | 89.2% | ||||
IMN long diameter | < 1.0 cm (n = 42) | 92.5% | 0.267 | 0.129 | 0.365(0.099–1.330) |
≥1.0 cm (n = 42) | 85.7% | ||||
Neoadjuvant chemotherapy | Performed (n = 66) | 92.3% | 0.108 | 0.167 | 0.242(0.034–1.626) |
Not performed (n = 18) | 77.0% | ||||
Axillary surgery | ALND (n = 74) | 88.9% | 0.889 | – | – |
SLNB (n = 10) | 90.0% | ||||
EQD2 of the IMN2) | 50.0–63.5 Gy (n = 35) | 85.5% | 0.544 | – | – |
63.6–70.4 Gy (n = 49) | 91.7% | ||||