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Table 1 Patient characteristics

From: Optimal radiotherapy for patients with internal mammary lymph node metastasis from breast cancer

Characteristics

 

Number of patients (%)

Age (years)

≤40

38 (45.2%)

 

> 40

46 (54.8%)

Laterality of breast cancer

Left breast

57 (67.9%)

 

Right breast

27 (32.1%)

Location of breast cancer

Inner or center part

66 (78.6%)

 

Outer part

18 (21.4%)

Histologic type

Invasive ductal carcinoma

78 (92.9%)

 

Others

6 (7.1%)

Histologic grade

1–2

45 (53.6%)

 

3

30 (35.7%)

 

Unknown

9 (10.7%)

Tumor subtype

ER+/or PR+/HER2-

32 (38.1%)

 

ER+/or PR+/HER2+

12 (14.3%)

 

ER−/PR−/HER2+

10 (11.9%)

 

ER−/PR−/HER2-

30 (35.7%)

cT stage

T1-T2

47 (56.0%)

 

T3-T4

37 (44.0%)

cN stage

N2b or N3b

63 (75.0%)

 

N3c

21 (25.0%)

Extent of IMN

Single ICS

37 (44.0%)

 

Multiple ICS

47 (56.0%)

Long diameter of the IMN

< 1.0 cm

42 (50.0%)

 

≥1.0 cm

42 (50.0%)

Type of breast surgery

Breast-conserving surgery

40 (47.6%)

 

Mastectomy

44 (52.4%)

Type of axillary surgery

Sentinel lymph node biopsy

10 (11.9%)

 

Axillary lymph node dissection

74 (88.1%)

Neoadjuvant chemotherapy

Performed

66 (78.6%)

 

Not performed

18 (21.4%)

EQD2 of the IMN1)

50.0–63.5 Gy

35 (41.7%)

(median, 63.6 Gy; range, 50–70.4 Gy)

63.6–70.4 Gy

49 (58.3%)

  1. 1)Radiotherapy dose was calculated using the EQD2 assuming the α/β ratio of 3.5 Gy. Abbreviations: IDC Invasive ductal carcinoma; ER Estrogen receptor, PR Progesterone receptor, HER2 Human epidermal growth factor receptor type 2, ICS Intercostal space, IMN Internal mammary node, EQD2 Biologically equivalent dose in 2 Gy fractions