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Table 3 Summary of the planning objectives and average results (uncertainty expressed as 1 standard deviation) for the main organs at risk investigated in the study

From: Intensity modulated proton therapy compared to volumetric modulated arc therapy in the irradiation of young female patients with hodgkin’s lymphoma. Assessment of risk of toxicity and secondary cancer induction

ParameterObjectiveRAIMPTp
Breasts
 Volume: 1808 ± 964 Range: [516–3886] cm3
  Mean [Gy]<4Gy4.7 ± 2.51.4 ± 1.2< 0.001
  D1% [Gy]Minimize20.6 ± 5.017.5 ± 7.00.03
Lungs
 Volume: 2260 ± 530 Range: [1183–3313] cm3
  Mean [Gy]< 10 Gy8.3 ± 2.65.9 ± 2.6< 0.001
  V20Gy [%]< 20%11.6 ± 6.511.0 ± 6.6< 0.001
  V5Gy [%]< 55–60%53.5 ± 15.435.8 ± 13.5< 0.001
Lungs-PTV
 Volume: 2118 ± 534 Range: [1034–3188] cm3
  Mean [Gy]< 10 Gy7.4 ± 2.24.9 ± 2.0< 0.001
  V20Gy [%]< 20%7.8 ± 4.17.1 ± 4.2< 0.001
  V5Gy [%]< 55–60%51.7 ± 14.933.2 ± 12.5< 0.001
Heart
 Volume: 557 ± 110 Range [403–728] cm3
  Mean [Gy]Minimize6.6 ± 3.84.9 ± 3.6< 0.001
  D1% [Gy]Minimize25.9 ± 10.025.3 ± 11.20.06
LAD
 Volume: 3.1 ± 0.6 Range: [2.3–4.4] cm3
  Mean [Gy]< 5 Gy5.6 ± 4.53.8 ± 5.40.002
  D1% [Gy]Minimize16.1v9.912.9 ± 11.90.08
LAD (prv)
 Volume: 11.2 ± 1.7 Range: [8.3–14.5] cm3
  Mean [Gy]< 5 Gy5.7 ± 4.64.0 ± 5.4< 0.001
  D1% [Gy]Minimize17.1 ± 10.013.6 ± 12.20.03
Left Ventricle
 Volume: 117 ± 48 Range [114–320] cm3
  Mean [Gy]< 5 Gy2.9 ± 2.21.6 ± 2.0< 0.001
  D1% [Gy]Minimize13.6 ± 11.611.5 ± 12.50.03
Thyroid
 Volume: 9.7 ± 4.3 Range: [6.3–20.9] cm3
  Mean [Gy]Minimize10.8 ± 9.08.6 ± 7.7< 0.001
  V25Gy [Gy]< 62.5 Gy20.6 ± 25.313.0 ± 14.50.03
Spine
  Volume: 38.6 ± 12.7 Range: [17.3–66.8] cm3
  D1% [Gy]Minimize26.5 ± 5.522.7 ± 5.60.06
Esophagus
 Volume: 27.3 ± 6.2 Range: [18.8 ± 39.2] cm3
  Mean [Gy]Minimize13.9 ± 4.812.8 ± 5.90.01
  D1% [Gy]Minimize29.3 ± 2.229.1 ± 2.60.1
Healthy Tissue
 V10Gy [%]Minimize12.3 ± 5.87.0 ± 3.40.001
 CI95%1.01.2 ± 0.11.1 ± 0.10.002
  1. RA RapidArc, IMPT Intensity modulated proton therapy, Prv planning risk volume, Dx% dose received by at least (maximum) x% of the volume, VxGy volume receiving x Gy