Skip to main content

Table 3 Summary of the planning objectives and average results (uncertainty expressed as 1 standard deviation) for the main organs at risk investigated in the study

From: Intensity modulated proton therapy compared to volumetric modulated arc therapy in the irradiation of young female patients with hodgkin’s lymphoma. Assessment of risk of toxicity and secondary cancer induction

Parameter

Objective

RA

IMPT

p

Breasts

 Volume: 1808 ± 964 Range: [516–3886] cm3

  Mean [Gy]

<4Gy

4.7 ± 2.5

1.4 ± 1.2

< 0.001

  D1% [Gy]

Minimize

20.6 ± 5.0

17.5 ± 7.0

0.03

Lungs

 Volume: 2260 ± 530 Range: [1183–3313] cm3

  Mean [Gy]

< 10 Gy

8.3 ± 2.6

5.9 ± 2.6

< 0.001

  V20Gy [%]

< 20%

11.6 ± 6.5

11.0 ± 6.6

< 0.001

  V5Gy [%]

< 55–60%

53.5 ± 15.4

35.8 ± 13.5

< 0.001

Lungs-PTV

 Volume: 2118 ± 534 Range: [1034–3188] cm3

  Mean [Gy]

< 10 Gy

7.4 ± 2.2

4.9 ± 2.0

< 0.001

  V20Gy [%]

< 20%

7.8 ± 4.1

7.1 ± 4.2

< 0.001

  V5Gy [%]

< 55–60%

51.7 ± 14.9

33.2 ± 12.5

< 0.001

Heart

 Volume: 557 ± 110 Range [403–728] cm3

  Mean [Gy]

Minimize

6.6 ± 3.8

4.9 ± 3.6

< 0.001

  D1% [Gy]

Minimize

25.9 ± 10.0

25.3 ± 11.2

0.06

LAD

 Volume: 3.1 ± 0.6 Range: [2.3–4.4] cm3

  Mean [Gy]

< 5 Gy

5.6 ± 4.5

3.8 ± 5.4

0.002

  D1% [Gy]

Minimize

16.1v9.9

12.9 ± 11.9

0.08

LAD (prv)

 Volume: 11.2 ± 1.7 Range: [8.3–14.5] cm3

  Mean [Gy]

< 5 Gy

5.7 ± 4.6

4.0 ± 5.4

< 0.001

  D1% [Gy]

Minimize

17.1 ± 10.0

13.6 ± 12.2

0.03

Left Ventricle

 Volume: 117 ± 48 Range [114–320] cm3

  Mean [Gy]

< 5 Gy

2.9 ± 2.2

1.6 ± 2.0

< 0.001

  D1% [Gy]

Minimize

13.6 ± 11.6

11.5 ± 12.5

0.03

Thyroid

 Volume: 9.7 ± 4.3 Range: [6.3–20.9] cm3

  Mean [Gy]

Minimize

10.8 ± 9.0

8.6 ± 7.7

< 0.001

  V25Gy [Gy]

< 62.5 Gy

20.6 ± 25.3

13.0 ± 14.5

0.03

Spine

  Volume: 38.6 ± 12.7 Range: [17.3–66.8] cm3

  D1% [Gy]

Minimize

26.5 ± 5.5

22.7 ± 5.6

0.06

Esophagus

 Volume: 27.3 ± 6.2 Range: [18.8 ± 39.2] cm3

  Mean [Gy]

Minimize

13.9 ± 4.8

12.8 ± 5.9

0.01

  D1% [Gy]

Minimize

29.3 ± 2.2

29.1 ± 2.6

0.1

Healthy Tissue

 V10Gy [%]

Minimize

12.3 ± 5.8

7.0 ± 3.4

0.001

 CI95%

1.0

1.2 ± 0.1

1.1 ± 0.1

0.002

  1. RA RapidArc, IMPT Intensity modulated proton therapy, Prv planning risk volume, Dx% dose received by at least (maximum) x% of the volume, VxGy volume receiving x Gy