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Table 1 Normal tissue complication parameters for the different models and endpoints applied in the study. The uncertainty values reported within brackets are derived from the original publications and correspond to 1 standard deviation

From: Intensity modulated proton therapy compared to volumetric modulated arc therapy in the irradiation of young female patients with hodgkin’s lymphoma. Assessment of risk of toxicity and secondary cancer induction

  

Lyman model parameters

Poisson-LQ model parameters

 

Organ

Endpoint

TD50, Gy

n

m

D50,Gy

Seriality

Ref

Heart

Death

52.4 [49.1–57.1]

1.30 [1.06–1.66]

1 [−1.27]

Gagliardi [16]

Lung

Pneumonitis

34.0 [nr]

0.90 [nr]

0.06 [nr]

Seppenwoolde [17]

Pneumonitis grade ≥ 2

30.8 [27–38]

0.99 [0.6–1.8]

0.37 [0.30–0.46]

Seppenwoolde [17]

Symptomatic or radiographic pneumonitis

21.9 [13.2–30.6]

0.80 [0.32–1.28]

0.37 [0.17–0.57]

Moiseenko [18]

Symptomatic fibrosis

25.0 [17.0–32.0]

0.85 [0.39–1.31]

0.15 [0.09–0.21]

Moiseenko [18]

Esophagus

Esophagitis grade ≥ 2

51.0 [40.0–63.0]

0.44 [0.25–0.79]

0.32 [0.25–0.43]

Chapet [19]

  1. nr not reported