Table 2 Toxicities
|  | Total (n = 9) | Level I cohort (n = 3) | Level II cohort (n = 3) | Level III cohort (n = 3) | ||||
|---|---|---|---|---|---|---|---|---|
|  | Grade 1–3 | Grade 3 | Grade 1–3 | Grade 3 | Grade 1–3 | Grade 3 | Grade 1–3 | Grade 3 |
Leucopenia | 4 | 0 | 0 | 0 | 2 | 0 | 2 | 0 |
Anemia | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Thrombocytopenia | 4 | 0 | 0 | 0 | 2 | 0 | 2 | 0 |
Increased ALT | 5 | 0 | 2 | 0 | 1 | 0 | 2 | 0 |
Increased alkaline-P | 6 | 0 | 3 | 0 | 0 | 0 | 3 | 0 |
Increased total bilirubin | 6 | 0 | 2 | 0 | 1 | 0 | 3 | 0 |
Increased creatinine | 2 | 0 | 1 | 0 | 1 | 0 | 0 | 0 |
Hypothyroidism | 3 | 0 | 1 | 0 | 0 | 0 | 2 | 0 |
Proteinuria | 6 | 0 | 2 | 0 | 1 | 0 | 3 | 0 |
Skin rash | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Hand numbness | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Hypertension | 9 | 5 | 3 | 1 | 3 | 2 | 3 | 2 |
Nausea/vomiting | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
Diarrhea | 3 | 2 | 1 | 1 | 1 | 1 | 1 | 0 |
Constipation | 2 | 0 | 1 | 0 | 1 | 0 | 0 | 0 |