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Table 2 Toxicities

From: Axitinib in combination with radiotherapy for advanced hepatocellular carcinoma: a phase I clinical trial

  Total (n = 9) Level I cohort (n = 3) Level II cohort (n = 3) Level III cohort (n = 3)
  Grade 1–3 Grade 3 Grade 1–3 Grade 3 Grade 1–3 Grade 3 Grade 1–3 Grade 3
Leucopenia 4 0 0 0 2 0 2 0
Anemia 1 0 1 0 0 0 0 0
Thrombocytopenia 4 0 0 0 2 0 2 0
Increased ALT 5 0 2 0 1 0 2 0
Increased alkaline-P 6 0 3 0 0 0 3 0
Increased total bilirubin 6 0 2 0 1 0 3 0
Increased creatinine 2 0 1 0 1 0 0 0
Hypothyroidism 3 0 1 0 0 0 2 0
Proteinuria 6 0 2 0 1 0 3 0
Skin rash 1 0 0 0 0 0 1 0
Hand numbness 1 0 1 0 0 0 0 0
Hypertension 9 5 3 1 3 2 3 2
Nausea/vomiting 1 1 1 1 0 0 0 0
Diarrhea 3 2 1 1 1 1 1 0
Constipation 2 0 1 0 1 0 0 0