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Table 4 Summary of literature on radiation therapy as a bridge to transplantation in HCC

From: Clinical outcome and pathologic correlation of stereotactic body radiation therapy as a bridge to transplantation for advanced hepatocellular carcinoma: a case series

Study, year(ref.) Pre-operative radiotherapy Liver transplantation
No. of patients /lesions Child–Pugh class Dose (Gy)/no. of fractions Infield control rate (%) Toxicity ≥ grade 3/RILD No. of patient Median time to LT (months) Pathologic response Post-transplant outcome Median follow-up (months)
Sandroussi, 2010 [8] 10/10 A: 40%
B: 50%
C: 10%
33/1–6 100% 0/0 5 5.2 SpR: 3 (60%)
MpR: 1 (20%)
NpR: 1 (20%)
6-month RFS: 70% 6
Andolino, 2011 [9] 60/NA A: 60%
B: 40%
40–44/3 NA 21/NA 23 7 NA 2-year OS: 96%
2-year PFS: 69%
27
Katz, 2011 [10] 18/21 A: 17%
B: 44%
C: 22%
NA:17%
50/10 100% 1/0 11 6 CpR: 2 (18.1%)
SpR: 3 (27.2%)
MpR 4 (36.6%)
NpR: 2 (18.1%)
1 liver recurrence
10 alive with NED
19.6
O'Connor, 2012 [11] 10/11 A: 70%
B: 20%
C: 10%
51/3 100% 0/0 10 3.8 NpR: 3 (30%) 5-year OS: 100%
5-year DFS: 100%
62
Guarneri, 2016 [12] 8/13 A: 62%
B: 38%
36–48/3–5 100% 0/1 8 3.2 CpR: 8 (61.5%)
SpR: 1 (7.7%)
MpR: 2 (15.3%)
NpR: 2 (15.3%)
No liver recurrence
7 alive with NED
9.6
Moore, 2017 [13] 23/NA A: 57%
B: 43%
30/5
48/4
54/3
100% 0/1 11 4.8 CpR: 3 (27.3%)
SpR: 6 (54.5%)
MpR: 2 (18.2%)
Median OS: not reached
Median PFS: not reached
12
Mannina, 2017 [14] 38/51 A: 45%
B: 55%
36–45/3–5 NA NA/NA 38 8.8 CpR: 45% 1, 2, 3, 5-year OS: 92%, 86%, 77%, 73%
1, 2, 3, 5-year DFS: 91%, 85%, 74%, 74%
58
Gresswell, 2018 [15] 12/17 B: 58%
C: 42%
40/5 100% 0/0 11 5 CpR: 46% 1,2,3,4-year OS: 91%, 91%, 68%, 57% 40
Sapisochin, 2017 [16] 36/NA A: 61%
B: 39%
36/6 NA NA/NA 30 5.2 CpR: 4 (13.3%)
SpR: 12 (40%)
MpR: 11 (36.7%)
NpR: 3 (10%)
1,3,5-year OS: 83%, 75%,75% 29.6
Present series 14/26 A: 79%
B: 14%
C: 7%
45/5 100% 4/1 14 8.4 CpR: 3 (27.3%)
SpR: 3 (27.3%)
MpR: 5 (45.4%)
Median OS: 37.8 months
Median RFS: 18.3 months
30.2
  1. CpR, complete pathologic response; LT, liver transplantation; MpR, minimal pathological response; NA, not available; NpR, no pathologic response; OS, overall survival; PFS, progression-free survival; RFS, recurrence-free survival; RILD, radiation-induced liver disease; SpR, significant pathologic response