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Table 4 Multivariate analyses of risk factors regarding 5-year overall and disease-free survivals using Cox regression model among different quality of neck dissection, a sensitivity test (85%), n = 1605

From: Postoperative radiotherapy is associated with improved survival in pT1-2N1 oral and oropharyngeal cancer without adequate neck dissection

 

LNs < 18

18 LNs < 25

25 LNs

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

Overall survival

With RT

0.61 (0.45–0.81)

0.001

0.70 (0.45–1.11)

0.128

0.99 (0.76–1.28)

0.931

Male

0.88 (0.66–1.18)

0.397

1.14 (0.69–1.87)

0.606

1.06 (0.81–1.39)

0.672

Age

1.04 (1.03–1.05)

 < 0.001

1.04 (1.02–1.06)

0.001

1.01 (1.001–1.02)

0.038

Pathological T classification: T2

1.70 (1.28–2.25)

 < 0.001

1.88 (1.17–3.03)

0.009

1.69 (1.30–2.20)

 < 0.001

Differentiation: poorly

1.10 (0.79–1.54)

0.562

1.27 (0.77–2.10)

0.357

1.20 (0.90–1.61)

0.209

Site: oropharynx

0.48 (0.33–0.69)

 < 0.001

0.52 (0.29–0.93)

0.028

0.33 (0.23–0.47)

 < 0.001

Disease-specific survival

With RT

0.62 (0.41–0.93)

0.020

1.06 (0.57–1.99)

0.848

1.20 (0.86–1.67)

0.297

Male

0.76 (0.51–1.13)

0.169

1.12 (0.58–2.19)

0.732

0.97 (0.70–1.36)

0.868

Age

1.02 (1.01–1.04)

0.011

1.03 (0.99–1.06)

0.054

1.00 (0.98–1.01)

0.696

Pathological T classification: T2

1.65 (1.11–2.46)

0.013

2.01 (1.04–3.91)

0.039

1.49 (1.07–2.08)

0.017

Differentiation: poorly

1.24 (0.79–1.96)

0.353

1.71 (0.87–3.35)

0.119

1.38 (0.97–1.98)

0.077

Site: oropharynx

0.37 (0.21–0.63)

 < 0.001

0.17 (0.06–0.48)

0.001

0.29 (0.19–0.46)

 < 0.001

  1. LNs lymph nodes, RT radiotherapy
  2. *Adjusted for age, gender, pathological T classification, differentiation, site, race, marital and insurance