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Table 4 Multivariate analyses of risk factors regarding 5-year overall and disease-free survivals using Cox regression model among different quality of neck dissection, a sensitivity test (85%), n = 1605

From: Postoperative radiotherapy is associated with improved survival in pT1-2N1 oral and oropharyngeal cancer without adequate neck dissection

  LNs < 18 18 LNs < 25 25 LNs
HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value
Overall survival
With RT 0.61 (0.45–0.81) 0.001 0.70 (0.45–1.11) 0.128 0.99 (0.76–1.28) 0.931
Male 0.88 (0.66–1.18) 0.397 1.14 (0.69–1.87) 0.606 1.06 (0.81–1.39) 0.672
Age 1.04 (1.03–1.05)  < 0.001 1.04 (1.02–1.06) 0.001 1.01 (1.001–1.02) 0.038
Pathological T classification: T2 1.70 (1.28–2.25)  < 0.001 1.88 (1.17–3.03) 0.009 1.69 (1.30–2.20)  < 0.001
Differentiation: poorly 1.10 (0.79–1.54) 0.562 1.27 (0.77–2.10) 0.357 1.20 (0.90–1.61) 0.209
Site: oropharynx 0.48 (0.33–0.69)  < 0.001 0.52 (0.29–0.93) 0.028 0.33 (0.23–0.47)  < 0.001
Disease-specific survival
With RT 0.62 (0.41–0.93) 0.020 1.06 (0.57–1.99) 0.848 1.20 (0.86–1.67) 0.297
Male 0.76 (0.51–1.13) 0.169 1.12 (0.58–2.19) 0.732 0.97 (0.70–1.36) 0.868
Age 1.02 (1.01–1.04) 0.011 1.03 (0.99–1.06) 0.054 1.00 (0.98–1.01) 0.696
Pathological T classification: T2 1.65 (1.11–2.46) 0.013 2.01 (1.04–3.91) 0.039 1.49 (1.07–2.08) 0.017
Differentiation: poorly 1.24 (0.79–1.96) 0.353 1.71 (0.87–3.35) 0.119 1.38 (0.97–1.98) 0.077
Site: oropharynx 0.37 (0.21–0.63)  < 0.001 0.17 (0.06–0.48) 0.001 0.29 (0.19–0.46)  < 0.001
  1. LNs lymph nodes, RT radiotherapy
  2. *Adjusted for age, gender, pathological T classification, differentiation, site, race, marital and insurance