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Table 3 Multivariate analyses of risk factors regarding 5-year overall and disease-free survivals using Cox regression model among different quality of neck dissection, n = 1765

From: Postoperative radiotherapy is associated with improved survival in pT1-2N1 oral and oropharyngeal cancer without adequate neck dissection

  LNs < 18 18 LNs < 25 25 LNs
HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value
Overall survival
With RT 0.64 (0.49–0.84) 0.001 0.73 (0.48–1.13) 0.158 0.96 (0.75–1.24) 0.769
Male 0.86 (0.66–1.13) 0.279 1.01 (0.64–1.60) 0.961 1.08 (0.83–1.40) 0.557
Age 1.03 (1.02–1.05)  < 0.001 1.04 (1.02–1.06)  < 0.001 1.01 (1.002–1.02) 0.022
Pathological T classification: T2 1.62 (1.23–2.12) 0.001 1.89 (1.21–2.96) 0.005 1.72 (1.34–2.22)  < 0.001
Differentiation: poorly 1.11 (0.81–1.52) 0.515 1.29 (0.80–2.10) 0.301 1.18 (0.89–1.55) 0.246
Site: oropharynx 0.43 (0.30–0.62)  < 0.001 0.46 (0.26–0.82) 0.008 0.34 (0.24–0.47)  < 0.001
Disease-specific survival
With RT 0.66 (0.45–0.97) 0.033 1.07 (0.59–1.96) 0.822 1.12 (0.81–1.56) 0.491
Male 0.74 (0.51–1.08) 0.122 1.08 (0.58–2.01) 0.820 1.01 (0.73–1.40) 0.957
Age 1.02 (1.001–1.03) 0.043 1.03 (1.004–1.06) 0.023 1.00 (0.99–1.01) 0.715
Pathological T classification: T2 1.54 (1.06–2.25) 0.025 2.27 (1.21–4.26) 0.011 1.54 (1.12–2.12) 0.008
Differentiation: poorly 1.26 (0.82–1.93) 0.297 1.68 (0.88–3.22) 0.117 1.34 (0.95–1.89) 0.098
Site: oropharynx 0.33 (0.19–0.55)  < 0.001 0.19 (0.07–0.50) 0.001 0.28 (0.18–0.44)  < 0.001
  1. LNs lymph nodes, RT radiotherapy
  2. *Adjusted for age, gender, pathological T classification, differentiation, site, race, marital and insurance