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Table 3 Multivariate analyses of risk factors regarding 5-year overall and disease-free survivals using Cox regression model among different quality of neck dissection, n = 1765

From: Postoperative radiotherapy is associated with improved survival in pT1-2N1 oral and oropharyngeal cancer without adequate neck dissection

 

LNs < 18

18 LNs < 25

25 LNs

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

Overall survival

With RT

0.64 (0.49–0.84)

0.001

0.73 (0.48–1.13)

0.158

0.96 (0.75–1.24)

0.769

Male

0.86 (0.66–1.13)

0.279

1.01 (0.64–1.60)

0.961

1.08 (0.83–1.40)

0.557

Age

1.03 (1.02–1.05)

 < 0.001

1.04 (1.02–1.06)

 < 0.001

1.01 (1.002–1.02)

0.022

Pathological T classification: T2

1.62 (1.23–2.12)

0.001

1.89 (1.21–2.96)

0.005

1.72 (1.34–2.22)

 < 0.001

Differentiation: poorly

1.11 (0.81–1.52)

0.515

1.29 (0.80–2.10)

0.301

1.18 (0.89–1.55)

0.246

Site: oropharynx

0.43 (0.30–0.62)

 < 0.001

0.46 (0.26–0.82)

0.008

0.34 (0.24–0.47)

 < 0.001

Disease-specific survival

With RT

0.66 (0.45–0.97)

0.033

1.07 (0.59–1.96)

0.822

1.12 (0.81–1.56)

0.491

Male

0.74 (0.51–1.08)

0.122

1.08 (0.58–2.01)

0.820

1.01 (0.73–1.40)

0.957

Age

1.02 (1.001–1.03)

0.043

1.03 (1.004–1.06)

0.023

1.00 (0.99–1.01)

0.715

Pathological T classification: T2

1.54 (1.06–2.25)

0.025

2.27 (1.21–4.26)

0.011

1.54 (1.12–2.12)

0.008

Differentiation: poorly

1.26 (0.82–1.93)

0.297

1.68 (0.88–3.22)

0.117

1.34 (0.95–1.89)

0.098

Site: oropharynx

0.33 (0.19–0.55)

 < 0.001

0.19 (0.07–0.50)

0.001

0.28 (0.18–0.44)

 < 0.001

  1. LNs lymph nodes, RT radiotherapy
  2. *Adjusted for age, gender, pathological T classification, differentiation, site, race, marital and insurance