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Table 1 Studies investigated interactions between the gut microbiome and radiotherapy effectiveness

From: Radiotherapy and the gut microbiome: facts and fiction

Study Study subjects Treatment Bacterial identification Key findings
Nam et al. [16] 9 patients with gynecological cancer and 6 healthy controls Pelvic RT 50.4 Gy/ 25 fractions/5 weeks 16 s RNA The numbers of species-level taxa were severely reduced and the abundance of each community largely changed after RT
Kim et al. [30] Male 8–10-week-old C57BL/6 mice A single 8 Gy dose using a Cobalt 60 source irradiator 16 s RNA Irradiation increased the level of the genera Alistipes in the large intestine and increased the level of the genus Corynebacterium in the small intestine
Jang et al. [31] 45 patients with rectal cancer Pelvic RT, 50.0–54.0 Gy/ 25–30 fractions 16 s RNA Differences in microbial community composition and functions were observed between CR and non-CR patients. Bacteroidales were relatively more abundant in patients with non-CR than those with CR
Uribe-Herranz et al. [34] A melanoma model, a HPV E6/7-expressing lung and cervical cancer model in tumor-bearing mice 21 Gy using an XRAD320iX 16 s RNA Gut microbiota can be modulated to improve RT-mediated antitumor responses. Vancomycin pretreatment enhanced the antitumor effects of RT in tumor-bearing mice
Cui et al. [36] C57BL/6 mice Total body irradiation exposure of 5 Gy 16 s RNA Circadian rhythm is a key modulator in maintaining intestinal microflora balance. Mtnr1a and Mtnr1b might be involved in the circadian rhythm-shaped gut bacterial community
Crawford et al. [43] CONV-R WT FVB/N mice Mark I 137Cs irradiator (106 cGy/min for a total dose of 10–22 Gy) Metabolomics Fiaf deficiency results in loss of resistance of villus endothelial and lymphocyte populations to radiation-induced apoptosis
  1. CR complete response, RT radiotherapy