Fig. 3
From: Radiotherapy and the gut microbiome: facts and fiction
Crosstalks between gut microbiome, microbial metabolites and immune microenvironment may explain the underlying mechanism of gut immune alliance. Notes: Microbial metabolites induced by radiotherapy could enter the bloodstream transported to the liver, brain and other organs of the body. Immune microenvironment is thus changed and may modulate radio-sensitivity and radiation injury. GLP-1 glucagon-like peptide-1, PYY peptide tyrosine tyrosine, LPS lipopolysaccharide, IPA indolepropionic acid, APC antigen-presenting cell, TLR toll-like receptor